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  3. CTSE - cathepsin E Gene

CTSE - cathepsin E Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：组织蛋白酶 E

种属: Homo sapiens

同用名: CATE

基因 ID: 1510 | 基因类型: protein coding

关于 CTSE

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,009,264-206,023,895 (from NCBI)

This gene has 9 transcripts (splice variants), 142 orthologues and 9 paralogues. Biased expression in stomach (RPKM 543.0) and duodenum (RPKM 112.5).

功能概要

该基因编码 A1 肽酶家族的一个成员。该基因的可变剪接导致多个转录变体。这些变体中至少有一个编码一种前原蛋白，该蛋白经过蛋白水解处理后生成成熟酶。这种酶是一种天冬氨酸内肽酶，可能参与抗原加工和分泌蛋白的成熟。已在神经变性中观察到该基因表达升高。[RefSeq 提供，2015 年 11 月]

This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature Enzyme. This Enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015]

CTSE 基因产物(5)

mRNA Protein Name
XM_011509245.2 XP_011507547.1 cathepsin E isoform X2
XM_011509244.2 XP_011507546.1 cathepsin E isoform X1
NM_148964.3 NP_683865.1 cathepsin E isoform b precursor
NM_001317331.2 NP_001304260.1 cathepsin E isoform c
NM_001910.4 NP_001901.1 cathepsin E isoform a preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aspartic-type endopeptidase activity IDA
IDA: 通过直接分析推断
7789521 GOA
enables peptidase activity IDA
IDA: 通过直接分析推断
16997486 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
IDA: 通过直接分析推断
8765029 GOA
involved in proteolysis IDA
IDA: 通过直接分析推断
16997486 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endosome IDA
IDA: 通过直接分析推断
7983070 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CTSE 蛋白结构

A1_Propeptide

A1_Propeptide: A1 Propeptide (21 - 49)

Asp

Asp: Eukaryotic aspartyl protease (77 - 394)

  • 0
  • 100
  • 200
  • 300
  • 396 a.a.
蛋白主名 其他名称

cathepsin E

erythrocyte membrane aspartic proteinase

slow-moving proteinase

重组 CTSE 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7750 Cathepsin E Protein, Human (HEK293, His) P14091 (S20-P396) ≥95%

关联疾病

疾病名称 别名
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
Gastric Cancer

Stomach Cancer

Stomach Carcinoma

Gastric Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Tetanus

Lockjaw

Clostridial Tetanus

Infection Due To Clostridium Tetani

Lock-Jaw
Gastric Tubular Adenocarcinoma

Tubular Adenocarcinoma Of Stomach
Ceroid Lipofuscinosis, Neuronal, 10

Neuronal Ceroid Lipofuscinosis Due To Cathepsin D Deficiency

Neuronal Ceroid Lipofuscinosis 10

CLN10

Cathepsin D Deficiency

Congenital Neuronal Ceroid Lipofuscinosis

Neuronal Ceroid Lipofuscinosis Cathepsin D-Deficient

Cln10 Disease

Ceroid Lipofuscinosis, Neuronal, Cathepsin D-Deficient

Cln10 Disease, Adult

Cln10 Disease, Congenital

Cln10 Disease, Juvenile

Cln10 Disease, Late Infantile

Ceroid Lipofuscinosis Neuronal Cathepsin D-Deficient

Cathepsin D Deficient Neuronal Ceroid Lipofuscinosis

Congenital Ncl

Lipofuscinosis, Ceroid, Neuronal, Type 10

Neuronal Ceroid Lipofuscinosis, Congenital
Gastric Papillary Adenocarcinoma

Papillary Adenocarcinoma Of Stomach
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03331 CTSE Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03332 Ctse Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03333 Ctse Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CTSE VGNC VGNC:71554
Canis familiaris CTSE VGNC VGNC:39710
Mus musculus CTSE MGD MGI:107361
Rattus norvegicus CTSE RGD RGD:2446
Felis catus CTSE VGNC VGNC:61267
Others CTSE NCBI
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