DTX3L - deltex E3 ubiquitin ligase 3L Gene

中文名称：deltex E3 泛素连接酶 3L

种属: Homo sapiens

同用名: BBAP; RNF143

基因 ID: 151636 | 基因类型: protein coding

关于 DTX3L

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,564,338-122,575,203 (from NCBI)

This gene has 2 transcripts (splice variants), 355 orthologues and 4 paralogues. Ubiquitous expression in appendix (RPKM 14.2), spleen (RPKM 13.2) and 25 other tissues.

功能概要

DTX3L 作为 E3 泛素连接酶发挥作用 (Takeyama 等人，2003 [PubMed 12670957]) 。[OMIM 提供，2009 年 11 月]

DTX3L functions as an E3 ubiquitin Ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

DTX3L 基因产物(1)

mRNA	Protein	Name
NM_138287.3	NP_612144.1	E3 ubiquitin-protein ligase DTX3L

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables STAT family protein binding	IPI IPI: 通过物理相互作用推断	26479788	GOA
enables enzyme binding	IPI IPI: 通过物理相互作用推断	28525742	GOA
enables enzyme inhibitor activity	IMP IMP: 通过突变表型推断	24790097	GOA
enables histone H4K91 ubiquitin ligase activity	IDA IDA: 通过直接分析推断	19818714	GOA
enables histone binding	IDA IDA: 通过直接分析推断	19818714	GOA
enables histone binding	IPI IPI: 通过物理相互作用推断	26479788	GOA
enables histone ubiquitin ligase activity	IMP IMP: 通过突变表型推断	26479788	GOA
enables protein ADP-ribosyltransferase-substrate adaptor activity	IDA IDA: 通过直接分析推断	28525742	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16809771	GOA
enables ubiquitin-like protein ligase binding	IPI IPI: 通过物理相互作用推断	24790097	GOA
enables ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	19818714	GOA
enables ubiquitin-protein transferase activity	IMP IMP: 通过突变表型推断	23230272	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage checkpoint signaling	IMP IMP: 通过突变表型推断	28525742	GOA
involved in DNA repair-dependent chromatin remodeling	IMP IMP: 通过突变表型推断	19818714	GOA
involved in double-strand break repair	IMP IMP: 通过突变表型推断	23230272	GOA
involved in endosome to lysosome transport	IMP IMP: 通过突变表型推断	24790097	GOA
involved in negative regulation of ubiquitin-protein transferase activity	IMP IMP: 通过突变表型推断	24790097	GOA
involved in positive regulation of DNA-templated transcription	IGI IGI: 通过遗传相互作用推断	26479788	GOA
involved in positive regulation of chromatin binding	IGI IGI: 通过遗传相互作用推断	26479788	GOA
involved in positive regulation of defense response to virus by host	IGI IGI: 通过遗传相互作用推断	26479788	GOA
involved in positive regulation of protein binding	IMP IMP: 通过突变表型推断	26479788	GOA
involved in positive regulation of protein localization to early endosome	IMP IMP: 通过突变表型推断	24790097	GOA
involved in positive regulation of protein localization to nucleus	IGI IGI: 通过遗传相互作用推断	26479788	GOA
involved in positive regulation of receptor catabolic process	IMP IMP: 通过突变表型推断	24790097	GOA
involved in protein K48-linked ubiquitination	IDA IDA: 通过直接分析推断	26479788	GOA
involved in protein autoubiquitination	IMP IMP: 通过突变表型推断	24790097	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	26479788	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	16809771	GOA
colocalizes with early endosome	IDA IDA: 通过直接分析推断	24790097	GOA
located in lysosome	IDA IDA: 通过直接分析推断	24790097	GOA
colocalizes with nucleus	IDA IDA: 通过直接分析推断	26479788	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16809771	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	24790097	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DTX3L 蛋白结构

zf-RING_2

0
200
400
600
740 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase DTX3L

B-lymphoma- and BAL-associated protein

DTX3L 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DTX3L	Q8TDB6	UBE2K	Homo sapiens	P61086	Y2H Array	32814053
种属内	DTX3L	Q8TDB6	UBE2K	Homo sapiens	P61086	Validated Y2H	32814053
种属内	DTX3L	Q8TDB6	UBE2K	Homo sapiens	P61086	Y2H Pooling	32814053
种属内	DTX3L	Q8TDB6	SPG21	Homo sapiens	Q9NZD8	Y2H Array	32296183
种属内	DTX3L	Q8TDB6	SPG21	Homo sapiens	Q9NZD8	Y2H Prey Pooling	32296183
种属内	DTX3L	Q8TDB6	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
种属内	DTX3L	Q8TDB6	SPG21	Homo sapiens	Q9NZD8	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation	Intracranial Arteriovenous Malformation
Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To	Intracranial Arteriovenous Malformations
Bavm	Cerebral Arteriovenous Malformations
Intracranial Hemorrhage In Brain Cerebrovascular Malformations	Arteriovenous Malformation Of The Brain, Somatic
Intracranial Avm	Arteriovenous Malformations Cerebral

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04041	DTX3L Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	DTX3L	RGD	RGD:1565144
Macaca mulatta	DTX3L	VGNC	VGNC:71995
Felis catus	DTX3L	VGNC	VGNC:61651
Canis familiaris	DTX3L	VGNC	VGNC:40118
Mus musculus	DTX3L	MGD	MGI:2656973
Bos taurus	DTX3L	VGNC	VGNC:28239
Others	DTX3L	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DTX3L - deltex E3 ubiquitin ligase 3L Gene

关于 DTX3L

功能概要

DTX3L 基因产物(1)

DTX3L 蛋白结构

DTX3L 蛋白互作信息

关联疾病

直系同源

热门区域

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DTX3L - deltex E3 ubiquitin ligase 3L Gene

关于 DTX3L

功能概要

DTX3L 基因产物(1)

DTX3L 蛋白结构

DTX3L 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z