2. Gene
  3. NEK10 - NIMA related kinase 10 Gene

NEK10 - NIMA related kinase 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NIMA 相关激酶 10

种属: Homo sapiens

同用名: CILD44

基因 ID: 152110 | 基因类型: protein coding

关于 NEK10

Cytogenetic location: 3p24.1 Genomic coordinates (GRCh38): 3:27,106,484-27,369,383 (from NCBI)

This gene has 14 transcripts (splice variants), 172 orthologues, 8 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 2.8), brain (RPKM 0.3) and 6 other tissues.

功能概要

启用蛋白激酶活性。参与多个过程，包括粘膜纤毛清除；蛋白质磷酸化的正调节； ERK1 和 ERK2 级联的调节。蛋白激酶复合物的一部分。涉及原发性纤毛运动障碍 44。[由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase activity. Involved in several processes, including mucociliary clearance; positive regulation of protein phosphorylation; and regulation of ERK1 and ERK2 cascade. Part of protein kinase complex. Implicated in primary ciliary dyskinesia 44. [provided by Alliance of Genome Resources, Apr 2022]

NEK10 基因产物(13)

mRNA Protein Name
NM_001031741.5 NP_001026911.1 serine/threonine-protein kinase Nek10 isoform 1
NM_001304384.3 NP_001291313.1 serine/threonine-protein kinase Nek10 isoform 4
NM_001394963.1 NP_001381892.1 serine/threonine-protein kinase Nek10 isoform 5
NM_001394964.1 NP_001381893.1 serine/threonine-protein kinase Nek10 isoform 6
NM_001394965.1 NP_001381894.1 serine/threonine-protein kinase Nek10 isoform 7
NM_001394966.1 NP_001381895.1 serine/threonine-protein kinase Nek10 isoform 8
NM_001394967.1 NP_001381896.1 serine/threonine-protein kinase Nek10 isoform 9
NM_001394968.1 NP_001381897.1 serine/threonine-protein kinase Nek10 isoform 10
NM_001394969.1 NP_001381898.1 serine/threonine-protein kinase Nek10 isoform 11
NM_001394970.1 NP_001381899.1 serine/threonine-protein kinase Nek10 isoform 2
NM_001394971.1 NP_001381900.1 serine/threonine-protein kinase Nek10 isoform 7
NM_152534.6 NP_689747.3 serine/threonine-protein kinase Nek10 isoform 2
NM_199347.4 NP_955379.2 serine/threonine-protein kinase Nek10 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein kinase activity IDA
IDA: 通过直接分析推断
20956560 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mucociliary clearance IMP
IMP: 通过突变表型推断
31959991 GOA
involved in positive regulation of MAP kinase activity IMP
IMP: 通过突变表型推断
20956560 GOA
involved in positive regulation of protein autophosphorylation IDA
IDA: 通过直接分析推断
20956560 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
20956560 GOA
involved in regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
20956560 GOA
involved in regulation of cell cycle G2/M phase transition IMP
IMP: 通过突变表型推断
20956560 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein kinase complex IDA
IDA: 通过直接分析推断
20956560 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NEK10 蛋白结构

Pkinase

Pkinase: Protein kinase domain (519 - 779)

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  • 1172 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase Nek10

NIMA (never in mitosis gene a)- related kinase 10

关联疾病

疾病名称 别名
Ciliary Dyskinesia, Primary, 44

CILD44

Ciliary Dyskinesia, Primary, 44, Without Situs Inversus

Primary Ciliary Dyskinesia 44

Primary Ciliary Dyskinesia 44 Without Situs Inversus

Ciliary Dyskinesia, Primary, 44 Without Situs Inversus
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Spinocerebellar Ataxia, Autosomal Recessive 16

Autosomal Recessive Spinocerebellar Ataxia 16

SCAR16

Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency

Spinocerebellar Ataxia Autosomal Recessive Type 16

Spinocerebellar Ataxia, Autosomal Recessive, 16

Ataxia, Spinocerebellar, Autosomal Recessive, Type 16
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09191 NEK10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NEK10 MGD MGI:2685128
Felis catus NEK10 VGNC VGNC:63769
Macaca mulatta NEK10 VGNC VGNC:83929
Rattus norvegicus NEK10 RGD RGD:1564342
Canis familiaris NEK10 VGNC VGNC:43730
Bos taurus NEK10 VGNC VGNC:31992
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