1. Gene
  2. SPICE1 - spindle and centriole associated protein 1 Gene

SPICE1 - spindle and centriole associated protein 1 Gene

中文名称:纺锤体和中心粒相关蛋白 1

种属: Homo sapiens

同用名: SPICE; CCDC52

基因 ID: 152185 | 基因类型: protein coding

关于 SPICE1

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:113,442,718-113,515,156 (from NCBI)

This gene has 7 transcripts (splice variants) and 181 orthologues. Ubiquitous expression in testis (RPKM 3.6), endometrium (RPKM 3.3) and 25 other tissues.

功能概要

参与中期板块大会;有丝分裂纺锤体组装;和调节中心粒复制。位于中心粒;中心体;和主轴。 [由基因组资源联盟提供,2022 年 4 月]

Involved in metaphase plate congression; mitotic spindle assembly; and regulation of centriole replication. Located in centriole; centrosome; and spindle. [provided by Alliance of Genome Resources, Apr 2022]

SPICE1 基因产物(4)

mRNA Protein Name
NM_001331078.2 NP_001318007.1 spindle and centriole-associated protein 1
NM_001331079.2 NP_001318008.2 spindle and centriole-associated protein 1
NM_001387939.1 NP_001374868.1 spindle and centriole-associated protein 1
NM_144718.4 NP_653319.1 spindle and centriole-associated protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23455924 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in metaphase chromosome alignment IMP
IMP: 通过突变表型推断
20736305 GOA
involved in mitotic spindle assembly IMP
IMP: 通过突变表型推断
20736305 GOA
involved in regulation of centriole replication IMP
IMP: 通过突变表型推断
20736305 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centriole IDA
IDA: 通过直接分析推断
20736305 GOA
located in centrosome IDA
IDA: 通过直接分析推断
21399614 GOA
located in spindle IDA
IDA: 通过直接分析推断
20736305 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

spindle and centriole-associated protein 1

coiled-coil domain-containing protein 52

关联疾病

疾病名称 别名
Arthrogryposis Multiplex Congenita-3
Ciliary Dyskinesia, Primary, 43

CILD43

Primary Ciliary Dyskinesia 43

Ciliary Dyskinesia, Primary, 43, With Or Without Situs Inversus

Primary Ciliary Dyskinesia 43 With Or Without Situs Inversus

Ciliary Dyskinesia, Primary, 43 With Or Without Situs Inversus

Blepharocheilodontic Syndrome 1

Blepharocheilodontic Syndrome

Bcd Syndrome

Elschnig Syndrome

Clefting, Ectropion, And Conical Teeth

Lagophthalmia With Bilateral Cleft Lip And Palate

Blepharo-Cheilo-Odontic Syndrome

Bcds

Ectropion, Inferior, With Cleft Lip And/Or Palate

Blepharo-Cheilo-Dontic Syndrome

BCDS1

Ectropion Inferior Cleft Lip And Or Palate

Clefting-Ectropion-Conical Teeth Syndrome

Ectropion Inferior-Cleft Lip And/Or Palate Syndrome

Lagophthalmia-Cleft Lip And Palate Syndrome

Blepharocheilodontic Syndrome, Type 1

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SPICE1 RGD RGD:1310729
Canis familiaris SPICE1 VGNC VGNC:46740
Mus musculus SPICE1 MGD MGI:1196252
Bos taurus SPICE1 VGNC VGNC:35215
Felis catus SPICE1 VGNC VGNC:102848
Macaca mulatta SPICE1 VGNC VGNC:82732