CMTM8 - CKLF like MARVEL transmembrane domain containing 8 Gene

中文名称：含 CKLF 样 MARVEL 跨膜结构域 8

种属: Homo sapiens

同用名: CKLFSF8; CKLFSF8-V2

关于 CMTM8

功能概要

该基因属于趋化因子样因子基因超家族，是一个类似于趋化因子和跨膜 4 超家族的新家族。该基因是位于 3 号染色体簇中的几个趋化因子样因子基因之一。该基因充当肿瘤抑制因子，并在调节肿瘤细胞的迁移中发挥作用。编码的蛋白质被认为作为表皮生长因子诱导的信号传导的负调节剂起作用。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 2 月]

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene acts as a tumor suppressor, and plays a role in regulating the migration of tumor cells. The encoded protein is thought to function as a a negative regulator of epidermal growth factor-induced signaling. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]