Hif1a - hypoxia inducible factor 1, alpha subunit Gene

种属: Mus musculus

同用名: MOP1; bHLHe78; HIF1alpha; HIF1-alpha; HIF-1-alpha

基因 ID: 15251 | 基因类型: protein coding

关于 Hif1a

功能概要

This gene encodes the alpha subunit which, along with the beta subunit, forms a heterodimeric transcription factor that regulates the cellular and developmental response to reduced oxygen tension. The transcription factor has been shown to regulate genes involved in several biological processes, including erythropoiesis and angiogenesis which aid in increased delivery of oxygen to hypoxic regions. The transcription factor also plays a role in the induction of genes involved in cell proliferation and survival, energy metabolism, Apoptosis, and glucose and iron metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Hif1a 基因产物(3)

mRNA	Protein	Name
NM_001313919.1	NP_001300848.1	hypoxia-inducible factor 1-alpha isoform 1
NM_001313920.1	NP_001300849.1	hypoxia-inducible factor 1-alpha isoform 3
NM_010431.2	NP_034561.2	hypoxia-inducible factor 1-alpha isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	15456877	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	21856340	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	25587068	MGI
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	15456877	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	24030251	MGI
enables E-box binding	IMP IMP: 通过突变表型推断	24011070	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	25587068	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI IGI: 通过遗传相互作用推断	9113979	MGI
enables histone deacetylase binding	IPI IPI: 通过物理相互作用推断	19071119	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	8702901	MGI
enables protein heterodimerization activity	IDA IDA: 通过直接分析推断	26245371	MGI
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	9368100	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within B-1 B cell homeostasis	IMP IMP: 通过突变表型推断	11854513	MGI
acts upstream of TOR signaling	IMP IMP: 通过突变表型推断	20808783	MGI
acts upstream of or within angiogenesis	IMP IMP: 通过突变表型推断	14659802	MGI
acts upstream of apoptotic process	IMP IMP: 通过突变表型推断	17181398	MGI
acts upstream of or within blood vessel development	IMP IMP: 通过突变表型推断	9436976	MGI
acts upstream of or within blood vessel morphogenesis	IMP IMP: 通过突变表型推断	9606183	MGI
acts upstream of bone mineralization	IMP IMP: 通过突变表型推断	17181398	MGI
acts upstream of or within camera-type eye morphogenesis	IGI IGI: 通过遗传相互作用推断	22627278	MGI
acts upstream of or within cardiac ventricle morphogenesis	IMP IMP: 通过突变表型推断	9436976	MGI
acts upstream of or within cartilage development	IMP IMP: 通过突变表型推断	11691837	MGI
acts upstream of or within cell differentiation	IGI IGI: 通过遗传相互作用推断	16287860	MGI
acts upstream of or within cellular response to hypoxia	IGI IGI: 通过遗传相互作用推断	24011070	MGI
acts upstream of or within cerebral cortex development	IMP IMP: 通过突变表型推断	12972594	MGI
acts upstream of or within chondrocyte differentiation	IMP IMP: 通过突变表型推断	15073147	MGI
involved in collagen metabolic process	IMP IMP: 通过突变表型推断	18037992	MGI
involved in connective tissue replacement involved in inflammatory response wound healing	IMP IMP: 通过突变表型推断	18037992	MGI
acts upstream of or within digestive tract morphogenesis	IMP IMP: 通过突变表型推断	20808783	MGI
acts upstream of or within dopaminergic neuron differentiation	IGI IGI: 通过遗传相互作用推断	17215402	MGI
acts upstream of or within dopaminergic neuron differentiation	IMP IMP: 通过突变表型推断	17215402	MGI
involved in elastin metabolic process	IMP IMP: 通过突变表型推断	18037992	MGI
acts upstream of or within embryonic hemopoiesis	IMP IMP: 通过突变表型推断	16787915	MGI
acts upstream of or within embryonic placenta development	IGI IGI: 通过遗传相互作用推断	16287860	MGI
acts upstream of or within embryonic placenta development	IMP IMP: 通过突变表型推断	16287860	MGI
acts upstream of or within epithelial cell differentiation involved in mammary gland alveolus development	IMP IMP: 通过突变表型推断	12620994	MGI
involved in epithelial to mesenchymal transition	IMP IMP: 通过突变表型推断	18037992	MGI
acts upstream of or within glandular epithelial cell differentiation	IMP IMP: 通过突变表型推断	12620994	MGI
acts upstream of or within glandular epithelial cell maturation	IMP IMP: 通过突变表型推断	20808783	MGI
acts upstream of or within glucose homeostasis	IMP IMP: 通过突变表型推断	15328538	MGI
acts upstream of or within heart looping	IMP IMP: 通过突变表型推断	14659802	MGI
acts upstream of or within hemoglobin biosynthetic process	IMP IMP: 通过突变表型推断	16787915	MGI
acts upstream of or within hypoxia-inducible factor-1alpha signaling pathway	IDA IDA: 通过直接分析推断	8470821	MGI
acts upstream of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: 通过突变表型推断	20440072	MGI
acts upstream of or within intestinal epithelial cell maturation	IMP IMP: 通过突变表型推断	20808783	MGI
acts upstream of or within intracellular iron ion homeostasis	IMP IMP: 通过突变表型推断	16787915	MGI
acts upstream of or within intracellular oxygen homeostasis	IMP IMP: 通过突变表型推断	9436976	MGI
acts upstream of or within iris morphogenesis	IGI IGI: 通过遗传相互作用推断	22627278	MGI
acts upstream of or within lactate metabolic process	IMP IMP: 通过突变表型推断	15328538	MGI
acts upstream of or within lactation	IMP IMP: 通过突变表型推断	12620994	MGI
acts upstream of mesenchymal cell apoptotic process	IMP IMP: 通过突变表型推断	10328919	MGI
acts upstream of or within muscle cell cellular homeostasis	IMP IMP: 通过突变表型推断	15328538	MGI
acts upstream of or within negative regulation of TOR signaling	IMP IMP: 通过突变表型推断	20808783	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	17181398	MGI
acts upstream of or within negative regulation of bone mineralization	IMP IMP: 通过突变表型推断	17181398	MGI
acts upstream of or within negative regulation of growth	IMP IMP: 通过突变表型推断	11691837	MGI
acts upstream of or within negative regulation of mesenchymal cell apoptotic process	IMP IMP: 通过突变表型推断	10328919	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: 通过突变表型推断	12972594	MGI
involved in negative regulation of ossification	IMP IMP: 通过突变表型推断	22081627	MGI
acts upstream of or within negative regulation of thymocyte apoptotic process	IMP IMP: 通过突变表型推断	15456877	MGI
acts upstream of or within neural crest cell migration	IMP IMP: 通过突变表型推断	14659802	MGI
acts upstream of or within neural fold elevation formation	IMP IMP: 通过突变表型推断	10328919	MGI
acts upstream of neuroblast proliferation	IGI IGI: 通过遗传相互作用推断	17215402	MGI
acts upstream of neuron apoptotic process	IMP IMP: 通过突变表型推断	12972594	MGI
acts upstream of or within outflow tract morphogenesis	IMP IMP: 通过突变表型推断	9436976	MGI
involved in positive regulation of epithelial cell migration	IMP IMP: 通过突变表型推断	18037992	MGI
acts upstream of or within positive regulation of erythrocyte differentiation	IMP IMP: 通过突变表型推断	16787915	MGI
acts upstream of or within positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: 通过突变表型推断	20440072	MGI
acts upstream of or within positive regulation of macroautophagy	IMP IMP: 通过突变表型推断	19273585	MGI
involved in positive regulation of miRNA transcription	IMP IMP: 通过突变表型推断	25587068	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IGI IGI: 通过遗传相互作用推断	17215402	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	8702901	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	24011070	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	9113979	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	17284606	MGI
acts upstream of or within positive regulation of vascular endothelial growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	11691837	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	15456877	MGI
acts upstream of or within regulation of catalytic activity	IMP IMP: 通过突变表型推断	15328538	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: 通过突变表型推断	17437992	MGI
acts upstream of or within regulation of glycolytic process	IGI IGI: 通过遗传相互作用推断	17437992	MGI
acts upstream of or within regulation of thymocyte apoptotic process	IGI IGI: 通过遗传相互作用推断	15456877	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	12832481	MGI
acts upstream of or within response to hypoxia	IDA IDA: 通过直接分析推断	8702901	MGI
acts upstream of or within response to hypoxia	IGI IGI: 通过遗传相互作用推断	17437992	MGI
acts upstream of or within response to hypoxia	IMP IMP: 通过突变表型推断	9606183	MGI
involved in response to hypoxia	IMP IMP: 通过突变表型推断	25587068	MGI
acts upstream of or within response to muscle activity	IMP IMP: 通过突变表型推断	15328538	MGI
acts upstream of or within retina vasculature development in camera-type eye	IMP IMP: 通过突变表型推断	21212189	MGI
acts upstream of or within vasculature development	IGI IGI: 通过遗传相互作用推断	18653562	MGI
acts upstream of or within visual learning	IMP IMP: 通过突变表型推断	12972594	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in euchromatin	IDA IDA: 通过直接分析推断	25587068	MGI
located in motile cilium	IDA IDA: 通过直接分析推断	11818497	MGI
located in nuclear speck	IDA IDA: 通过直接分析推断	21546903	MGI
located in nucleus	IDA IDA: 通过直接分析推断	11691837	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

hypoxia-inducible factor 1-alpha

ARNT-interacting protein

Hif1a 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Hif1a	Q61221	Foxa2	Mus musculus	P35583	Pull Down	20609350
种属内	Hif1a	Q61221	Foxa2	Mus musculus	P35583	Anti Bait CoIP	20609350
种属内	Hif1a	Q61221	Rorc	Mus musculus	P51450-2	Anti Bait CoIP	21871655
种属内	Hif1a	Q61221	Rbfox3	Mus musculus	Q8BIF2	Anti Bait CoIP	21871655
种属内	Hif1a	Q61221	Arnt	Mus musculus	P53762	Anti Bait CoIP	20609350
种属内	Hif1a	Q61221	Arnt	Mus musculus	P53762	Pull Down	20609350

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06168	HIF1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-100947A	cis VH-298		/	否
HY-161838	ICT10336	Inhibitor	/	否
HY-107299	Trichilinin D		/	否
HY-112068	DM-NOFD	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Hif1a	NCBI	NCBI:3091

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Hif1a - hypoxia inducible factor 1, alpha subunit Gene

关于 Hif1a

功能概要

Hif1a 基因产物(3)

Hif1a 蛋白互作信息

直系同源

热门区域

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Hif1a - hypoxia inducible factor 1, alpha subunit Gene

关于 Hif1a

功能概要

Hif1a 基因产物(3)

Hif1a 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z