2. Gene
  3. Hrh2 - histamine receptor H2 Gene

Hrh2 - histamine receptor H2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组胺受体H2

种属: Mus musculus

同用名: H2R; HH2R

基因 ID: 15466 | 基因类型: protein coding

关于 Hrh2

Chromosome 13: 54,346,148-54,390,199 forward strand.GRCm39:CM001006.3

This gene has 3 transcripts (splice variants), 249 orthologues, 32 paralogues and is associated with 15 phenotypes. Broad expression in frontal lobe adult (RPKM 1.9), stomach adult (RPKM 1.8) and 18 other tissues.

功能概要

预计该基因编码的蛋白可启动 G 蛋白偶联胺受体活性；杂环化合物结合活性；和神经递质受体活性。作用于多个过程的上游或内部，包括胃酸分泌；学习或记忆；和毒素运输。预测位于膜中。预计在树突中活跃。预计是质膜的组成部分。在大脑中表达；早孕;胃;和子宫。与人类 HRH2（组胺受体 H2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable G protein-coupled amine receptor activity; heterocyclic compound binding activity; and neurotransmitter receptor activity. Acts upstream of or within several processes, including gastric acid secretion; learning or memory; and toxin transport. Predicted to be located in membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in brain; early conceptus; stomach; and uterus. Orthologous to human HRH2 (Histamine Receptor H2). [provided by Alliance of Genome Resources, Apr 2022]

Hrh2 基因产物(2)

mRNA Protein Name
NM_001413010.1 NP_001399939.1 histamine H2 receptor isoform 3
NM_001010973.3 NP_001010973.1 histamine H2 receptor isoform 1
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within digestive tract development IMP
IMP: 通过突变表型推断
10862789 MGI
acts upstream of or within epithelial cell morphogenesis IMP
IMP: 通过突变表型推断
10862789 MGI
acts upstream of or within gastric acid secretion IGI
IGI: 通过遗传相互作用推断
15476751 MGI
acts upstream of or within gastrin-induced gastric acid secretion IMP
IMP: 通过突变表型推断
10862789 MGI
acts upstream of or within gland development IMP
IMP: 通过突变表型推断
15476751 MGI
acts upstream of or within histamine-induced gastric acid secretion IMP
IMP: 通过突变表型推断
10862789 MGI
acts upstream of or within memory IMP
IMP: 通过突变表型推断
17145090 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: 通过突变表型推断
17145090 MGI
acts upstream of or within visual learning IMP
IMP: 通过突变表型推断
17145090 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Hrh2 蛋白结构

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (18 - 297)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (19 - 45)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (52 - 79)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (90 - 120)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (132 - 152)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (177 - 207)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (225 - 255)

7tmA_Histamine_H2R

7tmA_Histamine_H2R: cd15051 (265 - 290)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
蛋白主名 其他名称

histamine H2 receptor

gastric receptor I

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-101562 Inavolisib 99.96% 否
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06362 HRH2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06363 Hrh2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06364 Hrh2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hrh2 NCBI NCBI:3274
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