Hsf1 - heat shock factor 1 Gene

中文名称：热休克因子 1

种属: Mus musculus

同用名: HSTF; HSTF 1; Hsf1beta; Hsf1alpha

关于 Hsf1

功能概要

该基因编码的蛋白可启动 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性和染色质结合活性。参与冷诱导产热的正调控和基因表达的正调控。作用于多个过程的上游或内部，包括胚胎发育；配子世代；和肿瘤坏死因子产生的负调节。位于细胞质和原核中。部分含蛋白质复合物。以多种结构表达，包括消化系统；脑;泌尿生殖系统；心;和免疫系统。该基因的人类直系同源物与亨廷顿病有关。与人类 HSF1（热休克转录因子 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of gene expression. Acts upstream of or within several processes, including embryo development; gamete generation; and negative regulation of tumor necrosis factor production. Located in cytoplasm and pronucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and immune system. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HSF1 (heat shock transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]