HSF1 - heat shock transcription factor 1 Gene

中文名称：热休克转录因子 1

种属: Homo sapiens

同用名: HSTF1

基因 ID: 3297 | 基因类型: protein coding

关于 HSF1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,291,604-144,314,720 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 178 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 49.6), heart (RPKM 24.2) and 25 other tissues.

功能概要

该基因的产物是一种转录因子，在温度胁迫后被迅速诱导并结合热休克启动子元件 (HSE) 。这种蛋白质在调节寿命方面发挥作用。该基因的表达受到磷酸化的抑制，磷酸化促进热休克蛋白 90 的结合。[RefSeq 提供，2017 年 7 月]

The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017]

HSF1 基因产物(10)

mRNA	Protein	Name
XM_047421740.1	XP_047277696.1	heat shock factor protein 1 isoform X4
NM_005526.4	NP_005517.1	heat shock factor protein 1
XM_005272317.3	XP_005272374.1	heat shock factor protein 1 isoform X5
XM_011517006.3	XP_011515308.1	heat shock factor protein 1 isoform X7
XM_005272316.4	XP_005272373.1	heat shock factor protein 1 isoform X2
XM_047421741.1	XP_047277697.1	heat shock factor protein 1 isoform X4
XM_047421742.1	XP_047277698.1	heat shock factor protein 1 isoform X5
XM_017013377.3	XP_016868866.1	heat shock factor protein 1 isoform X3
XM_047421743.1	XP_047277699.1	heat shock factor protein 1 isoform X6
XM_005272315.4	XP_005272372.1	heat shock factor protein 1 isoform X1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	7935471	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	7760831	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	24504023	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	8926278	GOA
enables Hsp90 protein binding	IDA IDA: 通过直接分析推断	11583998	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	8926278	GOA
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	10561509	GOA
enables chromatin DNA binding	IDA IDA: 通过直接分析推断	21085490	GOA
enables general transcription initiation factor binding	IPI IPI: 通过物理相互作用推断	11005381	GOA
enables heat shock protein binding	IDA IDA: 通过直接分析推断	9727490	GOA
enables identical protein binding	IDA IDA: 通过直接分析推断	7935471	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	26727490	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9222587	GOA
enables protein heterodimerization activity	IDA IDA: 通过直接分析推断	9222587	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	16278218	GOA
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	25963659	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	24504023	GOA
enables translation elongation factor binding	IDA IDA: 通过直接分析推断	16554823	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in MAPK cascade	IDA IDA: 通过直接分析推断	12917326	GOA
involved in cellular response to cadmium ion	IDA IDA: 通过直接分析推断	10359787	GOA
involved in cellular response to copper ion	IDA IDA: 通过直接分析推断	15016915	GOA
involved in cellular response to diamide	IDA IDA: 通过直接分析推断	15016915	GOA
involved in cellular response to gamma radiation	IDA IDA: 通过直接分析推断	26359349	GOA
involved in cellular response to heat	IDA IDA: 通过直接分析推断	7760831	GOA
involved in cellular response to heat	IMP IMP: 通过突变表型推断	8455624	GOA
involved in cellular response to sodium arsenite	IDA IDA: 通过直接分析推断	15016915	GOA
involved in cellular response to unfolded protein	IDA IDA: 通过直接分析推断	15016915	GOA
involved in negative regulation of double-strand break repair via nonhomologous end joining	IMP IMP: 通过突变表型推断	26359349	GOA
involved in negative regulation of protein-containing complex assembly	IMP IMP: 通过突变表型推断	26359349	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	8926278	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	24504023	GOA
involved in positive regulation of macrophage differentiation	IMP IMP: 通过突变表型推断	24504023	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: 通过突变表型推断	18794143	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	10561509	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9341107	GOA
involved in protein-containing complex assembly	IDA IDA: 通过直接分析推断	11583998	GOA
involved in regulation of cellular response to heat	IDA IDA: 通过直接分析推断	11583998	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	7760831	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in PML body	IDA IDA: 通过直接分析推断	11514557	GOA
located in centrosome	IDA IDA: 通过直接分析推断	18794143	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	8455624	GOA
located in kinetochore	IDA IDA: 通过直接分析推断	18794143	GOA
located in mitotic spindle pole	IDA IDA: 通过直接分析推断	18794143	GOA
located in nuclear stress granule	IDA IDA: 通过直接分析推断	10359787	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	10359787	GOA
located in nucleus	IDA IDA: 通过直接分析推断	8455624	GOA
located in nucleus	IMP IMP: 通过突变表型推断	26359349	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	21085490	GOA
part of protein folding chaperone complex	IDA IDA: 通过直接分析推断	8455624	GOA
part of ribonucleoprotein complex	IDA IDA: 通过直接分析推断	16554823	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HSF1 蛋白结构

HSF_DNA-bind

Vert_HS_TF

0
100
200
300
400
500
529 a.a.

蛋白主名

其他名称

heat shock factor protein 1

重组 HSF1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P73918	HSF1 Protein, Human (His)	Q00613-1 (D2-S529)	≥95%

关联疾病

疾病名称

别名

Hermansky-Pudlak Syndrome 5

HPS5	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Delta Storage Pool Disease	Hermansky-Pudlak Syndrome, Type 5
Platelet Storage Pool Deficiency	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Heat-Shock Rna 1

Hsr1

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-145927	NXP800	Inhibitor	99.79%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-19356	Rocaglamide	Inhibitor	99.34%	否
HY-100872	KRIBB11	Inhibitor	99.54%	否
HY-103000	HSF1A	Activator	99.46%	否
HY-N0754	Eupalinolide A	Activator	99.92%	否
HY-149127	Rosolutamide	Activator	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	HSF1	VGNC	VGNC:41814
Rattus norvegicus	HSF1	RGD	RGD:620913
Bos taurus	HSF1	VGNC	VGNC:29981
Felis catus	HSF1	VGNC	VGNC:67661
Mus musculus	HSF1	MGD	MGI:96238
Macaca mulatta	HSF1	VGNC	VGNC:73531
Others	HSF1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HSF1 - heat shock transcription factor 1 Gene

关于 HSF1

功能概要

HSF1 基因产物(10)

HSF1 蛋白结构

重组 HSF1 蛋白

关联疾病

直系同源

热门区域

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HSF1 - heat shock transcription factor 1 Gene

关于 HSF1

功能概要

HSF1 基因产物(10)

HSF1 蛋白结构

重组 HSF1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z