MAPKAPK2 - MAPK activated protein kinase 2 Gene

中文名称：MAPK 活化蛋白激酶 2

种属: Homo sapiens

同用名: MK2; MK-2; MAPKAP-K2

关于 MAPKAPK2

功能概要

该基因编码 Ser/Thr 蛋白激酶家族的成员。该激酶通过 p38 MAP 激酶的直接磷酸化进行调节。与 p38 MAP 激酶结合，已知该激酶参与许多细胞过程，包括应激和炎症反应、核输出、基因表达调节和细胞增殖。热休克蛋白 HSP27 被证明是该激酶在体内的底物之一。已发现该基因的两个转录变体编码两种不同的亚型。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]