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  2. HSPBP1 - HSPA (Hsp70) binding protein 1 Gene

HSPBP1 - HSPA (Hsp70) binding protein 1 Gene

中文名称:HSPA (Hsp70) 结合蛋白 1

种属: Homo sapiens

同用名: FES1

基因 ID: 23640 | 基因类型: protein coding

关于 HSPBP1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,262,223-55,280,383 (from NCBI)

This gene has 9 transcripts (splice variants), 185 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 7.8), kidney (RPKM 7.4) and 25 other tissues.

功能概要

启用泛素蛋白连接酶结合活性。参与蛋白酶体泛素依赖性蛋白质分解代谢过程的正调控和蛋白质泛素化的正调控。预计在内质网中有活性。 [由基因组资源联盟提供,2022 年 4 月]

Enables ubiquitin protein Ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and positive regulation of protein ubiquitination. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

HSPBP1 基因产物(3)

mRNA Protein Name
NM_001130106.2 NP_001123578.1 hsp70-binding protein 1 isoform 2
NM_001297600.2 NP_001284529.1 hsp70-binding protein 1 isoform 1
NM_012267.5 NP_036399.3 hsp70-binding protein 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular sequestering activity IDA
IDA: 通过直接分析推断
21247889 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16169070 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
16207813 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
16831871 GOA
involved in positive regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
16831871 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in extracellular space IDA
IDA: 通过直接分析推断
16827227 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

hsp70-binding protein 1

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1

HSPBP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra HSPBP1 Q9NZL4 HSPA8 Homo sapiens Q96IS6
Y2H Array
25416956
Intra HSPBP1 Q9NZL4 HSPA8 Homo sapiens Q96IS6
Validated Y2H
25416956
Intra HSPBP1 Q9NZL4 HSPA8 Homo sapiens P11142
Y2H Pooling
16189514
Intra HSPBP1 Q9NZL4 HSPA8 Homo sapiens P11142
Y2H Pooling
16169070
Intra HSPBP1 Q9NZL4 HSPA8 Homo sapiens P11142
Y2H Array
25416956
Intra HSPBP1 Q9NZL4 HSPA8 Homo sapiens P11142
Anti Tag CoIP
33961781
Intra HSPBP1 Q9NZL4 HSPA2 Homo sapiens P54652
Anti Tag CoIP
33961781
Intra HSPBP1 Q9NZL4 HSPA2 Homo sapiens P54652
Anti Tag CoIP
35271311
Intra HSPBP1 Q9NZL4 HSPA2 Homo sapiens P54652
Y2H Prey Pooling
25416956
Intra HSPBP1 Q9NZL4 HSPA2 Homo sapiens P54652
Y2H Array
16713569
Intra HSPBP1 Q9NZL4 HSPA2 Homo sapiens P54652
Y2H Array
25416956
Intra HSPBP1 Q9NZL4 HSPA2 Homo sapiens P54652
Anti Tag CoIP
28514442
Intra HSPBP1 Q9NZL4 ELF1 Homo sapiens P32519
Anti Tag CoIP
33961781
Intra HSPBP1 Q9NZL4 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
Intra HSPBP1 Q9NZL4 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra HSPBP1 Q9NZL4 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinocerebellar Ataxia, Autosomal Recessive 16

Autosomal Recessive Spinocerebellar Ataxia 16

SCAR16

Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency

Spinocerebellar Ataxia Autosomal Recessive Type 16

Spinocerebellar Ataxia, Autosomal Recessive, 16

Ataxia, Spinocerebellar, Autosomal Recessive, Type 16

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus HSPBP1 MGD MGI:1913495
Rattus norvegicus HSPBP1 RGD RGD:628677
Canis familiaris HSPBP1 VGNC VGNC:53527
Others HSPBP1 NCBI