2. Gene
  3. ZNF746 - zinc finger protein 746 Gene

ZNF746 - zinc finger protein 746 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：锌指蛋白 746

种属: Homo sapiens

同用名: PARIS

基因 ID: 155061 | 基因类型: protein coding

关于 ZNF746

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:149,472,696-149,497,809 (from NCBI)

This gene has 6 transcripts (splice variants), 107 orthologues and 51 paralogues. Broad expression in testis (RPKM 10.6), bone marrow (RPKM 6.7) and 25 other tissues.

功能概要

启用 DNA 结合转录抑制活性，RNA 聚合酶 II 特异性； RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性；和泛素蛋白连接酶结合活性。参与 RNA 聚合酶 II 对转录的负调控；神经元死亡的正调节；和 RNA 聚合酶 II 对转录的正调控。位于细胞质和核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and ubiquitin protein Ligase binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of neuron death; and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZNF746 基因产物(4)

mRNA Protein Name
NM_001163474.2 NP_001156946.1 zinc finger protein 746 isoform 1
NM_001363517.2 NP_001350446.1 zinc finger protein 746 isoform 3
NM_001394198.1 NP_001381127.1 zinc finger protein 746 isoform 4
NM_152557.5 NP_689770.3 zinc finger protein 746 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
21376232 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
21376232 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
21376232 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21376232 GOA
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
21376232 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
21376232 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
31856708 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21376232 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21376232 GOA
involved in protein heterooligomerization IDA
IDA: 通过直接分析推断
31856708 GOA
involved in protein homooligomerization IDA
IDA: 通过直接分析推断
31856708 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
21376232 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZNF746 蛋白结构

DUF3669

DUF3669: Zinc finger protein (19 - 83)

KRAB

KRAB: KRAB box (106 - 136)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (453 - 475)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (524 - 548)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (566 - 588)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 644 a.a.
蛋白主名 其他名称

zinc finger protein 746

parkin-interacting substrate

ZNF746 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ZNF746 Q6NUN9 PRKN Homo sapiens O60260
Pull Down
21376232
Intra ZNF746 Q6NUN9 PRKN Homo sapiens O60260
Anti Tag CoIP
21376232
Intra ZNF746 Q6NUN9 PRKN Homo sapiens O60260
Anti Bait CoIP
21376232
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-121152 Chiisanoside / 否
HY-RS16172 ZNF746 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ZNF746 VGNC VGNC:37339
Felis catus ZNF746 VGNC VGNC:80767
Rattus norvegicus ZNF746 RGD RGD:1306209
Mus musculus ZNF746 MGD MGI:1916478
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