2. Gene
  3. CYP3A7 - cytochrome P450 family 3 subfamily A member 7 Gene

CYP3A7 - cytochrome P450 family 3 subfamily A member 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：细胞色素 P450 家族 3 亚家族 A 成员 7

种属: Homo sapiens

同用名: CP37; CYPIIIA7; P450HLp2; P450-HFLA; P-450111A7; P-450(HFL33)

基因 ID: 1551 | 基因类型: protein coding

关于 CYP3A7

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,705,036-99,735,196 (from NCBI)

This gene has 4 transcripts (splice variants), 678 orthologues and 3 paralogues. Biased expression in liver (RPKM 26.8), gall bladder (RPKM 5.5) and 4 other tissues.

功能概要

该基因编码细胞色素 P450 酶超家族的成员，参与药物代谢和胆固醇、类固醇和其他脂质的合成。这种酶使睾酮和脱氢表雄酮 3-硫酸盐羟基化，后者参与妊娠期间雌三醇的形成。该基因是染色体 7q21.1 上一组相关基因的一部分。自然发生的通读转录发生在该基因和下游 CYP3A51P 假基因之间，由 GeneID:100861540 表示。[RefSeq 提供，2015 年 1 月]

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes, which participate in drug metabolism and the synthesis of Cholesterol, Steroids and other lipids. This Enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015]

CYP3A7 基因产物(1)

mRNA Protein Name
NM_000765.5 NP_000756.3 cytochrome P450 3A7

CYP3A7 蛋白结构

p450

p450: Cytochrome P450 (39 - 492)

  • 0
  • 100
  • 200
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  • 400
  • 503 a.a.
蛋白主名 其他名称

cytochrome P450 3A7

aryl hydrocarbon hydroxylase

关联疾病

疾病名称 别名
Myopathy, Centronuclear, 4

CNM4

Centronuclear Myopathy 4

Congenital Myopathy With Internal Nuclei And Atypical Cores

Centronuclear Myopathy Type 4

Myopathy, Centronuclear, Type 4
Neonatal Abstinence Syndrome

Drug Withdrawal Syndrome In Newborn
Crigler-Najjar Syndrome, Type I

Crigler-Najjar Syndrome

Crigler-Najjar Syndrome Type 1

Bilirubin Udp Glucuronyl Transferase Deficiency

Crigler Najjar Syndrome

Crigler Najjar Syndrome, Type 1

Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency

Bilirubin-Ugt Deficiency

Hyperbilirubinemia, Crigler-Najjar Type I

Hblrcn1

Familial Nonhemolytic Unconjugated Hyperbilirubinemia

Hereditary Unconjugated Hyperbilirubinemia

Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1

Bilirubin-Ugt Deficiency Type 1

Crigler-Najjar Syndrome 1

CN1

Cn-I

Crigler-Najjar Syndrome Type I

Hereditary Unconjugated Hyperbilirubinaemia

Ugt Deficiency

Bilirubin Glucuronosyltransferase Deficiency

Crigler-Najjar Disease Or Syndrome

Deficiency Of Glucuronosyltransferase

Glucuronyl Transferase Deficiency

Glucuronyltransferase Deficiency

Udp Glucuronyl Transferase Deficiency

Cns - [Crigler-Najjar Syndrome]

Congenital Familial Nonhemolytic Jaundice
Dystonia 11, Myoclonic

Myoclonic Dystonia

Myoclonus-Dystonia Syndrome

DYT11

Myoclonic Dystonia 11

Alcohol-Responsive Dystonia

Myoclonus, Hereditary Essential

Dystonia-11, Myoclonic

Myoclonus-Dystonia

Dystonia 11

Hereditary Essential Myoclonus

Dystonia, Alcohol-Responsive

Dyt-Sgce

Dystonia, Alcohol Responsive

Dystonia-11

Dystonia, Myoclonic

Dystonia, Myoclonic, Type 11
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18642 CYP3cide Inhibitor 99.46% 否
HY-117605 N-Desmethyl Sildenafil Inhibitor 99.86% 否
HY-113482 1β-Hydroxydeoxycholic acid / 否
HY-RS03474 CYP3A7 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-113031 16a-Hydroxydehydroisoandrosterone / 否
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