Htr2a - 5-hydroxytryptamine (serotonin) receptor 2A Gene

中文名称：5-羟色胺 (血清素) 受体 2A

种属: Mus musculus

同用名: Htr2; Htr-2; 5-HT-2; 5-HT-2A; E030013E04

关于 Htr2a

功能概要

预计该基因编码的蛋白具有多种功能，包括 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine 结合活性； Gq/11-偶联血清素受体活性；和血清素结合活性。在脂肪细胞分化的正调节上游或正调节内起作用；磷酸化的正调控；和蛋白质定位到细胞骨架。预计位于多种细胞成分中，包括细胞体纤维；树突轴；和神经细胞体。预计是 G 蛋白偶联血清素受体复合物的一部分。预计在树突中活跃。预计是质膜的组成部分。以多种结构表达，包括消化系统；中枢神经系统;泌尿生殖系统；心;和感觉器官。该基因的人类直系同源基因与多种疾病有关，包括酒精使用障碍；神经性厌食症;严重抑郁症;肥胖;和强迫症。与人 HTR2A（5-羟色胺受体 2A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding activity; Gq/11-coupled serotonin receptor activity; and serotonin binding activity. Acts upstream of or within positive regulation of fat cell differentiation; positive regulation of phosphorylation; and protein localization to Cytoskeleton. Predicted to be located in several cellular components, including cell body fiber; dendritic shaft; and neuronal cell body. Predicted to be part of G protein-coupled serotonin receptor complex. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anorexia nervosa; major depressive disorder; obesity; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A). [provided by Alliance of Genome Resources, Apr 2022]