Slc6a4 - solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Gene

中文名称：溶质载体家族 6 (神经递质转运蛋白，血清素) ，成员 4

种属: Mus musculus

同用名: Htt; Sert; 5-HTT

关于 Slc6a4

功能概要

该基因编码的蛋白可启动单胺跨膜转运蛋白活性；神经递质跨膜转运体活性；和一氧化氮合酶结合活性。涉及多个过程，包括大脑形态发生；血清素摄取；和社会行为。在对有机物质的细胞反应上游或细胞反应中起作用。位于粘着斑和突触。以多种结构表达，包括早期孕体；肝;神经系统;子房;和极体。用于研究自闭症谱系障碍和婴儿猝死综合症。该基因的人类直系同源基因与多种疾病有关，包括酒精使用障碍；述情障碍;焦虑症（多种）；心脏病（多种）；和精神抑郁症（多种）。与人类 SLC6A4（溶质载体家族 6 成员 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables monoamine transmembrane transporter activity; neurotransmitter transmembrane transporter activity; and nitric-oxide synthase binding activity. Involved in several processes, including brain morphogenesis; serotonin uptake; and social behavior. Acts upstream of or within cellular response to organic substance. Located in focal adhesion and synapse. Is expressed in several structures, including early conceptus; liver; nervous system; ovary; and polar body. Used to study autism spectrum disorder and sudden infant death syndrome. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; alexithymia; anxiety disorder (multiple); heart disease (multiple); and mental depression (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4). [provided by Alliance of Genome Resources, Apr 2022]