Casp12 - caspase 12 Gene

中文名称：半胱天冬酶 12

种属: Rattus norvegicus

关于 Casp12

功能概要

该基因编码的蛋白可启动半胱氨酸型肽酶活性；内肽酶活性；和蛋白酶结合活性。参与多个过程，包括细胞对锰离子的反应；横纹肌细胞凋亡过程的正调控；和蛋白质自动加工。位于细胞质和细胞核中。用于研究坐骨神经病变。多种疾病的生物标志物，包括糖尿病（多种）；心脏病（多种）；神经退行性疾病（多种）；创伤后应激障碍；和输尿管梗阻。与人类 CASP12（caspase 12（基因/假基因））同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cysteine-type peptidase activity; endopeptidase activity; and protease binding activity. Involved in several processes, including cellular response to manganese ion; positive regulation of striated muscle cell apoptotic process; and protein autoprocessing. Located in cytosol and nucleus. Used to study sciatic neuropathy. Biomarker of several diseases, including diabetes mellitus (multiple); heart disease (multiple); neurodegenerative disease (multiple); post-traumatic stress disorder; and ureteral obstruction. Orthologous to human CASP12 (Caspase 12 (gene/pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]