CYP2J2 - cytochrome P450 family 2 subfamily J member 2 Gene

中文名称：细胞色素 P450 家族 2 亚家族 J 成员 2

种属: Homo sapiens

同用名: CPJ2; CYPIIJ2

基因 ID: 1573 | 基因类型: protein coding

关于 CYP2J2

Cytogenetic location: 1p32.1 Genomic coordinates (GRCh38): 1:59,893,308-59,969,212 (from NCBI)

This gene has 5 transcripts (splice variants), 151 orthologues and 15 paralogues. Biased expression in small intestine (RPKM 44.5), heart (RPKM 35.2) and 10 other tissues.

功能概要

该基因编码细胞色素 P450 酶超家族的成员。细胞色素 P450 蛋白是单加氧酶，可催化许多涉及药物代谢和胆固醇、类固醇和其他脂质合成的反应。这种蛋白质定位于内质网，被认为是负责心脏组织中内源性花生四烯酸环氧化的主要酶。已发现该基因的多个转录变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant Enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

CYP2J2 基因产物(1)

mRNA	Protein	Name
NM_000775.4	NP_000766.2	cytochrome P450 2J2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables arachidonate 11,12-epoxygenase activity	IDA IDA: 通过直接分析推断	11901223	GOA
enables arachidonate 14,15-epoxygenase activity	IDA IDA: 通过直接分析推断	11901223	GOA
enables arachidonate epoxygenase activity	IDA IDA: 通过直接分析推断	8631948	GOA
enables isomerase activity	IDA IDA: 通过直接分析推断	19737933	GOA
enables linoleic acid epoxygenase activity	IDA IDA: 通过直接分析推断	11901223	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in epoxygenase P450 pathway	IDA IDA: 通过直接分析推断	8631948	GOA
involved in icosanoid metabolic process	IDA IDA: 通过直接分析推断	19737933	GOA
involved in linoleic acid metabolic process	IDA IDA: 通过直接分析推断	11901223	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CYP2J2 蛋白结构

p450

0
100
200
300
400
502 a.a.

蛋白主名

其他名称

cytochrome P450 2J2

albendazole monooxygenase (hydroxylating)

关联疾病

疾病名称

别名

Atherosclerosis Susceptibility

Atherosclerosis	Atherosclerosis, Susceptibility To
ATHS	Atherogenic Lipoprotein Phenotype
Alp	Arteriosclerosis

Hemopericardium

Haemopericardium	Pericardial Effusion
Haematopericardium	Pneumohemopericardium
Pericardium Haemorrhage	Haemorrhagic Pericarditis

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Cardiovascular Disease
Disease Of Subdivision Of Hemolymphoid System	Disorder Of Cardiovascular System
Cardiovascular Diseases

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N0319	Salvianolic acid C	Inhibitor	99.94%	否
HY-N0515	Ophiopogonin D		99.54%	否
HY-117026	LKY-047	Inhibitor	99.94%	否
HY-E70482	Human CYP2J2,Low-Reductase		/	否
HY-RS03465	CYP2J2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-122508	Hydroxyebastine		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CYP2J2	RGD	RGD:620007
Macaca mulatta	CYP2J2	VGNC	VGNC:99873
Felis catus	CYP2J2	VGNC	VGNC:103321
Canis familiaris	CYP2J2	VGNC	VGNC:50354

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CYP2J2 - cytochrome P450 family 2 subfamily J member 2 Gene

关于 CYP2J2

功能概要

CYP2J2 基因产物(1)

CYP2J2 蛋白结构

关联疾病

直系同源

热门区域

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CYP2J2 - cytochrome P450 family 2 subfamily J member 2 Gene

关于 CYP2J2

功能概要

CYP2J2 基因产物(1)

CYP2J2 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z