DAB2 - DAB adaptor protein 2 Gene

中文名称：DAB 衔接蛋白 2

种属: Homo sapiens

同用名: DOC2; DOC-2

基因 ID: 1601 | 基因类型: protein coding

关于 DAB2

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:39,371,677-39,424,980 (from NCBI)

This gene has 17 transcripts (splice variants), 291 orthologues and 11 paralogues. Broad expression in placenta (RPKM 111.0), kidney (RPKM 73.8) and 20 other tissues.

功能概要

该基因编码丝裂原反应性磷蛋白。它在正常卵巢上皮细胞中表达，但在卵巢癌细胞系中表达下调或缺失，表明其作为肿瘤抑制因子的作用。该蛋白结合 GRB2 的 SH3 结构域，GRB2 是一种衔接蛋白，可通过其 C 末端富含脯氨酸的序列将酪氨酸激酶受体与 SOS (Ras 的鸟嘌呤核苷酸交换因子) 偶联，因此可以通过以下方式调节生长因子/Ras 通路与 SOS 竞争与 GRB2 的结合。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 10 月]

This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

DAB2 基因产物(2)

mRNA	Protein	Name
NM_001244871.2	NP_001231800.1	disabled homolog 2 isoform 2
NM_001343.4	NP_001334.2	disabled homolog 2 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables SMAD binding	IDA IDA: 通过直接分析推断	11387212	GOA
enables cargo receptor activity	IMP IMP: 通过突变表型推断	16984970	GOA
enables clathrin adaptor activity	IMP IMP: 通过突变表型推断	16984970	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11387212	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
NOT involved in integrin-mediated signaling pathway	IMP IMP: 通过突变表型推断	19581412	GOA
involved in leading edge cell differentiation	IMP IMP: 通过突变表型推断	19581412	GOA
involved in negative regulation of androgen receptor signaling pathway	IMP IMP: 通过突变表型推断	16267015	GOA
involved in negative regulation of apoptotic process	IDA IDA: 通过直接分析推断	15734730	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: 通过突变表型推断	12805222	GOA
involved in negative regulation of protein binding	IMP IMP: 通过突变表型推断	12805222	GOA
involved in negative regulation of protein localization to plasma membrane	IMP IMP: 通过突变表型推断	19581412	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	12805222	GOA
involved in positive regulation of SMAD protein signal transduction	IDA IDA: 通过直接分析推断	11387212	GOA
involved in positive regulation of Wnt signaling pathway, planar cell polarity pathway	IMP IMP: 通过突变表型推断	12805222	GOA
involved in positive regulation of cell migration	IMP IMP: 通过突变表型推断	19581412	GOA
involved in positive regulation of clathrin-dependent endocytosis	IMP IMP: 通过突变表型推断	16984970	GOA
involved in positive regulation of early endosome to late endosome transport	IMP IMP: 通过突变表型推断	21995445	GOA
involved in positive regulation of endocytosis	IMP IMP: 通过突变表型推断	19581412	GOA
involved in positive regulation of epithelial to mesenchymal transition	IDA IDA: 通过直接分析推断	15734730	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: 通过突变表型推断	12805222	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: 通过突变表型推断	12805222	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	12805222	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: 通过直接分析推断	11387212	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in clathrin-coated pit	IDA IDA: 通过直接分析推断	12857860	GOA
located in clathrin-coated vesicle	IDA IDA: 通过直接分析推断	19581412	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DAB2 蛋白结构

PID

0
200
400
600
770 a.a.

蛋白主名

其他名称

disabled homolog 2

DAB2, clathrin adaptor protein

DAB2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DAB2	P98082	SMAD2	Homo sapiens	Q15796	Anti Bait CoIP	11387212
种属内	DAB2	P98082	SMAD2	Homo sapiens	Q15796	Pull Down	11387212
种属内	DAB2	P98082	SMAD3	Homo sapiens	P84022	Anti Bait CoIP	11387212
种属内	DAB2	P98082	SMAD3	Homo sapiens	P84022	Pull Down	11387212
种属内	DAB2	P98082	NCK1	Homo sapiens	P16333	Peptide Array	17474147
种属内	DAB2	P98082	GRB2	Homo sapiens	P62993	Peptide Array	17474147
种属内	DAB2	P98082	GRB2	Homo sapiens	P62993	Y2H Pooling	20936779
种属内	DAB2	P98082	LRP6	Homo sapiens	O75581	Anti Tag CoIP	22491013

种属间: 跨种属相互作用 种属内: 同种属相互作用

DAB2 抗体

目录号	产品名	应用	反应物种
HY-P83107	DAB2 Antibody (YA2852)	WB, IHC-P, IP	Human

关联疾病

疾病名称

别名

Teratocarcinoma

Mixed Embryonal Carcinoma And Teratoma

Hypercholesterolemia, Familial, 4

Hypercholesterolemia, Autosomal Recessive	Arh
FHCL4	Autosomal Recessive Hypercholesterolemia
Arh1	Arh2
Autosomal Recessive Hypercholesterolemia 1	Autosomal Recessive Hypercholesterolemia 2
Fhcb1	Fhcb2
Hypercholesterolemia, Autosomal Recessive, 1, Formerly	Arh1, Formerly
Fhcb1, Formerly	Hypercholesterolemia, Autosomal Recessive, 2, Formerly
Arh2, Formerly	Fhcb2, Formerly
Familial Autosomal Recessive Hypercholesterolemia	Hypercholesterolemia, Familial, Autosomal Recessive
Hypercholesterolemia, Familial, Type 4

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Lactocele

Galactocele	Galactocoele
Lacteal Cyst

Macular Degeneration, Age-Related, 4

Age Related Macular Degeneration 4	ARMD4
Macular Degeneration, Age-Related, Type 4

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Deafness, Autosomal Recessive 17

DFNB17	Autosomal Recessive Nonsyndromic Deafness 17
Autosomal Recessive Deafness 17

Donnai-Barrow Syndrome

Faciooculoacousticorenal Syndrome	Dbs/Foar Syndrome
Foar Syndrome	Diaphragmatic Hernia-Exomphalos-Hypertelorism Syndrome
Facio-Oculo-Acoustico-Renal Syndrome	Diaphragmatic Hernia, Exomphalos, Absent Corpus Callosum, Hypertelorism, Myopia, Sensorineural Deafness, And Proteinuria
Diaphragmatic Hernia-Hypertelorism-Myopia-Deafness Syndrome	Holmes-Schepens Syndrome
Syndrome Of Ocular And Facial Anomalies, Telecanthus And Deafness	DBS
Diaphragmatic Hernia Exomphalos Absent Corpus Callosum Hypertelorism Myopia Sensorineural Deafness And Proteinuria	Diaphragmatic Hernia-Exomphalos-Corpus Callosum Agenesis
Diaphragmatic Hernia-Hypertelorism-Myopia-Hearing Loss Syndrome	Syndrome Of Ocular And Facial Anomalies, Telecanthus And Hearing Loss
Donnai Barrow Syndrome

Cervical Non-Keratinizing Squamous Cell Carcinoma

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia	Familial Hyperbetalipoproteinaemia
Familial Hypercholesteremia	Fredrickson Type Iia Hyperlipoproteinemia
Fredrickson Type Iia Lipidaemia	Hyperbetalipoproteinemia
Type Ii Hyperlipidemia	Familial Hypercholesterolæmia
Familial Hypercholesterolaemia	Fh
Hypercholesterolemia Familial	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03511	DAB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS03512	DAB2IP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-112114	DTPA-DAB2		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	DAB2	RGD	RGD:621007
Mus musculus	DAB2	MGD	MGI:109175
Canis familiaris	DAB2	VGNC	VGNC:39759
Bos taurus	DAB2	VGNC	VGNC:27865
Felis catus	DAB2	VGNC	VGNC:61329
Macaca mulatta	DAB2	VGNC	VGNC:71724

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DAB2 - DAB adaptor protein 2 Gene

关于 DAB2

功能概要

DAB2 基因产物(2)

DAB2 蛋白结构

DAB2 蛋白互作信息

DAB2 抗体

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

DAB2 - DAB adaptor protein 2 Gene

关于 DAB2

功能概要

DAB2 基因产物(2)

DAB2 蛋白结构

DAB2 蛋白互作信息

DAB2 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z