2. Gene
  3. DGKA - diacylglycerol kinase alpha Gene

DGKA - diacylglycerol kinase alpha Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：二酰甘油激酶α

种属: Homo sapiens

同用名: DAGK; DAGK1; DGK-alpha

基因 ID: 1606 | 基因类型: protein coding

关于 DGKA

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,931,162-55,954,023 (from NCBI)

This gene has 49 transcripts (splice variants), 263 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 36.2), skin (RPKM 31.7) and 19 other tissues.

功能概要

该基因编码的蛋白质属于真核二酰基甘油激酶家族。它充当调节剂，与蛋白激酶 C 竞争细胞内信号通路中的第二信使甘油二酯。它还在磷脂酰肌醇的再合成和将二酰基甘油磷酸化为磷脂酸方面发挥重要作用。已经为该基因鉴定了几种编码不同同种型的转录物变体。[RefSeq 提供，2017 年 4 月]

The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Several transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2017]

DGKA 基因产物(21)

mRNA Protein Name
NM_001345.5 NP_001336.2 diacylglycerol kinase alpha isoform a
NM_001351033.2 NP_001337962.1 diacylglycerol kinase alpha isoform a
NM_001351034.2 NP_001337963.1 diacylglycerol kinase alpha isoform a
NM_001351035.1 NP_001337964.1 diacylglycerol kinase alpha isoform b
NM_001351036.2 NP_001337965.1 diacylglycerol kinase alpha isoform c
NM_001351037.1 NP_001337966.1 diacylglycerol kinase alpha isoform c
NM_001351038.2 NP_001337967.1 diacylglycerol kinase alpha isoform d
NM_001351039.2 NP_001337968.1 diacylglycerol kinase alpha isoform d
NM_001351040.2 NP_001337969.1 diacylglycerol kinase alpha isoform d
NM_001413596.1 NP_001400525.1 diacylglycerol kinase alpha isoform a
NM_001413597.1 NP_001400526.1 diacylglycerol kinase alpha isoform a
NM_001413598.1 NP_001400527.1 diacylglycerol kinase alpha isoform a
NM_001413599.1 NP_001400528.1 diacylglycerol kinase alpha isoform e
NM_001413600.1 NP_001400529.1 diacylglycerol kinase alpha isoform e
NM_001413601.1 NP_001400530.1 diacylglycerol kinase alpha isoform e
NM_001413602.1 NP_001400531.1 diacylglycerol kinase alpha isoform f
NM_001413603.1 NP_001400532.1 diacylglycerol kinase alpha isoform f
NM_001413604.1 NP_001400533.1 diacylglycerol kinase alpha isoform g
NM_201444.3 NP_958852.1 diacylglycerol kinase alpha isoform a
NM_201445.2 NP_958853.1 diacylglycerol kinase alpha isoform a
NM_201554.2 NP_963848.1 diacylglycerol kinase alpha isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP-dependent diacylglycerol kinase activity IDA
IDA: 通过直接分析推断
2175712 GOA
enables kinase activity IDA
IDA: 通过直接分析推断
18004883 GOA
enables lipid binding IDA
IDA: 通过直接分析推断
22627129 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in diacylglycerol metabolic process IDA
IDA: 通过直接分析推断
2175712 GOA
involved in glycerolipid metabolic process IDA
IDA: 通过直接分析推断
22627129 GOA
involved in lipid phosphorylation IDA
IDA: 通过直接分析推断
2175712 GOA
involved in phosphatidic acid biosynthetic process IDA
IDA: 通过直接分析推断
2175712 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
2175712 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DGKA 蛋白结构

DAG_kinase_N

DAG_kinase_N: Diacylglycerol kinase N-terminus (2 - 86)

DAG_kinase_N

DAG_kinase_N: Diacylglycerol kinase N-terminus (90 - 110)

EF-hand_6

EF-hand_6: EF-hand domain (115 - 139)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (206 - 253)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (270 - 321)

DAGK_cat

DAGK_cat: Diacylglycerol kinase catalytic domain (376 - 500)

DAGK_acc

DAGK_acc: Diacylglycerol kinase accessory domain (521 - 701)

  • 0
  • 200
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  • 600
  • 735 a.a.
蛋白主名 其他名称

diacylglycerol kinase alpha

80 kDa diacylglycerol kinase

DGKA 抗体

目录号 产品名 应用 反应物种
HY-P83116 DGKA Antibody (YA2861) WB, IHC-P, IP Human

关联疾病

疾病名称 别名
Lymphoproliferative Syndrome, X-Linked, 1

Lymphomatoid Papulosis

Duncan Disease

Purtilo Syndrome

X-Linked Lymphoproliferative Syndrome

Xlp

X-Linked Lymphoproliferative Disease

XLP1

Lyp

Lymphoproliferative Disease, X-Linked

Xlpd

X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency

Ebv Infection, Severe, Susceptibility To

Ebvs

Immunodeficiency 5

Imd5

X-Linked Lymphoproliferative Syndrome 1

Epstein-Barr Virus Infection, Familial Fatal

Ebv Infection, Severe

Infectious Mononucleosis, Severe

Infectious Mononucleosis, Severe, Susceptibility To

Immunodeficiency, X-Linked Progressive Combined Variable

Epstein Barr Virus Infection, Familial Fatal

X-Linked Progressive Combined Variable Immunodeficiency 5

Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males

Familial Fatal Epstein-Barr Infection

Severe Susceptibility To Ebv Infection

Severe Susceptibility To Infectious Mononucleosis

Sap Deficiency

Sh2d1a/Slam-Associated Protein Deficiency

X-Linked Lymphoproliferative Syndrome Type 1

X-Linked Progressive Combined Variable Immunodeficiency

Lymphoproliferative Syndrome, X-Linked

Sap

X-Linked Lymphoproliferative Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03715 DGKA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus DGKA VGNC VGNC:28024
Canis familiaris DGKA VGNC VGNC:39915
Rattus norvegicus DGKA RGD RGD:70904
Felis catus DGKA VGNC VGNC:61458
Macaca mulatta DGKA VGNC VGNC:71780
Mus musculus DGKA MGD MGI:102952
Others DGKA NCBI
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