2. Gene
  3. DGKB - diacylglycerol kinase beta Gene

DGKB - diacylglycerol kinase beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：二酰甘油激酶β

种属: Homo sapiens

同用名: DGK; DAGK2; DGK-BETA

基因 ID: 1607 | 基因类型: protein coding

关于 DGKB

Cytogenetic location: 7p21.2 Genomic coordinates (GRCh38): 7:14,145,049-14,974,858 (from NCBI)

This gene has 13 transcripts (splice variants), 208 orthologues and 9 paralogues. Biased expression in brain (RPKM 7.2), adrenal (RPKM 0.9) and 2 other tissues.

功能概要

二酰甘油激酶 (DGK) 是第二信使二酰甘油 (DAG) 细胞内浓度的调节因子，因此在细胞过程中起着关键作用。已鉴定出九种哺乳动物同种型，它们由不同的基因编码。哺乳动物 DGK 同工酶包含一个保守的催化 (激酶) 结构域和一个富含半胱氨酸的结构域 (CRD) 。该基因编码的蛋白质是二酰基甘油激酶，β 同种型。已经为该基因发现了几种编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2017 年 4 月]

Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]

DGKB 基因产物(19)

mRNA Protein Name
NM_001350705.1 NP_001337634.1 diacylglycerol kinase beta isoform 1
NM_001350706.2 NP_001337635.1 diacylglycerol kinase beta isoform 1
NM_001350707.2 NP_001337636.1 diacylglycerol kinase beta isoform 3
NM_001350708.1 NP_001337637.1 diacylglycerol kinase beta isoform 3
NM_001350709.2 NP_001337638.1 diacylglycerol kinase beta isoform 3
NM_001350711.2 NP_001337640.1 diacylglycerol kinase beta isoform 4
NM_001350712.1 NP_001337641.1 diacylglycerol kinase beta isoform 4
NM_001350714.2 NP_001337643.1 diacylglycerol kinase beta isoform 4
NM_001350715.1 NP_001337644.1 diacylglycerol kinase beta isoform 5
NM_001350716.2 NP_001337645.1 diacylglycerol kinase beta isoform 5
NM_001350717.2 NP_001337646.1 diacylglycerol kinase beta isoform 6
NM_001350718.1 NP_001337647.1 diacylglycerol kinase beta isoform 6
NM_001350719.2 NP_001337648.1 diacylglycerol kinase beta isoform 6
NM_001350720.1 NP_001337649.1 diacylglycerol kinase beta isoform 7
NM_001350721.2 NP_001337650.1 diacylglycerol kinase beta isoform 7
NM_001350722.2 NP_001337651.1 diacylglycerol kinase beta isoform 8
NM_001350723.2 NP_001337652.1 diacylglycerol kinase beta isoform 8
NM_001350724.2 NP_001337653.1 diacylglycerol kinase beta isoform 9
NM_145695.2 NP_663733.1 diacylglycerol kinase beta isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP-dependent diacylglycerol kinase activity IDA
IDA: 通过直接分析推断
11719522 GOA
enables lipid binding IDA
IDA: 通过直接分析推断
22627129 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in glycerolipid metabolic process IDA
IDA: 通过直接分析推断
22627129 GOA
involved in lipid phosphorylation IDA
IDA: 通过直接分析推断
11719522 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
11719522 GOA
NOT located in nucleus IDA
IDA: 通过直接分析推断
11719522 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
11719522 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DGKB 蛋白结构

DAG_kinase_N

DAG_kinase_N: Diacylglycerol kinase N-terminus (3 - 149)

EF-hand_7

EF-hand_7: EF-hand domain pair (154 - 221)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (245 - 295)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (310 - 360)

DAGK_cat

DAGK_cat: Diacylglycerol kinase catalytic domain (438 - 562)

DAGK_acc

DAGK_acc: Diacylglycerol kinase accessory domain (583 - 762)

  • 0
  • 200
  • 400
  • 600
  • 804 a.a.
蛋白主名 其他名称

diacylglycerol kinase beta

90 kDa diacylglycerol kinase

关联疾病

疾病名称 别名
Hermansky-Pudlak Syndrome 1

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

HPS1

Delta Storage Pool Disease

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

Hermansky-Pudlak Syndrome, Type 1

Platelet Storage Pool Deficiency
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03716 DGKB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus DGKB VGNC VGNC:102575
Bos taurus DGKB VGNC VGNC:28025
Macaca mulatta DGKB VGNC VGNC:71782
Rattus norvegicus DGKB RGD RGD:2488
Mus musculus DGKB MGD MGI:2442474
Canis familiaris DGKB VGNC VGNC:39916
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