2. Gene
  3. SLC5A8 - solute carrier family 5 member 8 Gene

SLC5A8 - solute carrier family 5 member 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 5 成员 8

种属: Homo sapiens

同用名: AIT; SMCT; SMCT1

基因 ID: 160728 | 基因类型: protein coding

关于 SLC5A8

Cytogenetic location: 12q23.1-q23.2 Genomic coordinates (GRCh38): 12:101,155,493-101,210,238 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 263 orthologues and 11 paralogues. Biased expression in thyroid (RPKM 19.8), kidney (RPKM 2.8) and 1 other tissue.

功能概要

已证明 SLC5A8 通过被动机制转运碘化物 (Rodriguez 等人，2002 [PubMed 12107270]) ，并通过钠偶联机制转运单羧酸盐和短链脂肪酸 (Gopal 等人，2004 [PubMed 15322102]) 。在肾脏中，SLC5A8 作为一种高亲和力的钠偶联乳酸盐转运蛋白，参与乳酸的重吸收和血乳酸水平的维持 (Thangaraju 等人，2006 [PubMed 16873376]) 。[OMIM 提供，2008 年 12 月]

SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).[supplied by OMIM, Dec 2008]

SLC5A8 基因产物(1)

mRNA Protein Name
NM_145913.5 NP_666018.3 sodium-coupled monocarboxylate transporter 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables monocarboxylate:sodium symporter activity IDA
IDA: 通过直接分析推断
14966140 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
30604288 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acetate transport IDA
IDA: 通过直接分析推断
14966140 GOA
involved in chloride transport IDA
IDA: 通过直接分析推断
19864324 GOA
involved in iodide transport IDA
IDA: 通过直接分析推断
12107270 GOA
involved in lactate transport IDA
IDA: 通过直接分析推断
14966140 GOA
involved in nicotinate transport IDA
IDA: 通过直接分析推断
14966140 GOA
involved in nitrate transmembrane transport IDA
IDA: 通过直接分析推断
19864324 GOA
involved in propanoate transmembrane transport IDA
IDA: 通过直接分析推断
14966140 GOA
involved in pyruvate transport IDA
IDA: 通过直接分析推断
14966140 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
12107270 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC5A8 蛋白结构

SSF

SSF: Sodium:solute symporter family (45 - 449)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 610 a.a.
蛋白主名 其他名称

sodium-coupled monocarboxylate transporter 1

apical iodide transporter

关联疾病

疾病名称 别名
Pancreatic Colloid Cystadenoma

Mucinous Cystadenoma Of Pancreas
Pellagra

Niacin Deficiency

Niacin-Tryptophan Deficiency

Pellagroid Syndrome
Diversion Colitis
Fetal Adenoma

Microfollicular Adenoma
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13294 SLC5A8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SLC5A8 VGNC VGNC:77737
Bos taurus SLC5A8 VGNC VGNC:34911
Canis familiaris SLC5A8 VGNC VGNC:46451
Rattus norvegicus SLC5A8 RGD RGD:1564146
Felis catus SLC5A8 VGNC VGNC:65406
Mus musculus SLC5A8 MGD MGI:2384916
Others SLC5A8 NCBI
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