DGKQ - diacylglycerol kinase theta Gene

中文名称：二酰甘油激酶θ

种属: Homo sapiens

同用名: DAGK; DAGK4; DAGK7

基因 ID: 1609 | 基因类型: protein coding

关于 DGKQ

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:958,887-973,569 (from NCBI)

This gene has 5 transcripts (splice variants), 186 orthologues and 9 paralogues. Ubiquitous expression in small intestine (RPKM 9.9), duodenum (RPKM 8.3) and 25 other tissues.

功能概要

该基因编码的蛋白质包含三个富含半胱氨酸的结构域、一个富含脯氨酸的区域和一个具有重叠 Ras 关联结构域的 pleckstrin 同源结构域。它定位于细胞核的斑点区域，并在细胞信号转导过程中介导 PI 循环中二酰基甘油再生磷脂酰肌醇 (PI) 。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]

DGKQ 基因产物(1)

mRNA	Protein	Name
NM_001347.4	NP_001338.2	diacylglycerol kinase theta

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP-dependent diacylglycerol kinase activity	IDA IDA: 通过直接分析推断	9099683	GOA
enables ATP-dependent diacylglycerol kinase activity	IMP IMP: 通过突变表型推断	23091060	GOA
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	17664281	GOA
enables kinase binding	IPI IPI: 通过物理相互作用推断	15632189	GOA
enables phospholipase binding	IPI IPI: 通过物理相互作用推断	12799190	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10066731	GOA
enables transmembrane receptor protein tyrosine kinase activator activity	IGI IGI: 通过遗传相互作用推断	22732145	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: 通过突变表型推断	24369117	GOA
involved in cAMP-mediated signaling	IDA IDA: 通过直接分析推断	17664281	GOA
involved in cellular response to bile acid	IMP IMP: 通过突变表型推断	23767959	GOA
involved in diacylglycerol metabolic process	IDA IDA: 通过直接分析推断	9099683	GOA
involved in glycerolipid metabolic process	IDA IDA: 通过直接分析推断	22627129	GOA
involved in lipid phosphorylation	IDA IDA: 通过直接分析推断	9099683	GOA
involved in negative regulation of gene expression	IMP IMP: 通过突变表型推断	24369117	GOA
involved in negative regulation of peptidyl-threonine phosphorylation	IDA IDA: 通过直接分析推断	22732145	GOA
involved in negative regulation of peptidyl-threonine phosphorylation	IGI IGI: 通过遗传相互作用推断	22732145	GOA
involved in phosphatidic acid biosynthetic process	IDA IDA: 通过直接分析推断	9099683	GOA
involved in phosphatidic acid biosynthetic process	IMP IMP: 通过突变表型推断	23610160	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: 通过突变表型推断	15632189	GOA
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	24369117	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: 通过直接分析推断	22732145	GOA
involved in regulation of G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	22732145	GOA
involved in regulation of TORC1 signaling	IMP IMP: 通过突变表型推断	23767959	GOA
involved in regulation of cholesterol metabolic process	IMP IMP: 通过突变表型推断	24369117	GOA
involved in regulation of cortisol biosynthetic process	IMP IMP: 通过突变表型推断	24369117	GOA
involved in regulation of gluconeogenesis	IMP IMP: 通过突变表型推断	23767959	GOA
involved in regulation of progesterone biosynthetic process	IMP IMP: 通过突变表型推断	24369117	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	17664281	GOA
involved in response to cAMP	IDA IDA: 通过直接分析推断	23610160	GOA
involved in thrombin-activated receptor signaling pathway	IDA IDA: 通过直接分析推断	15632189	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	15632189	GOA
located in cytoskeleton	IDA IDA: 通过直接分析推断	10066731	GOA
located in cytosol	IDA IDA: 通过直接分析推断	10066731	GOA
located in endosome	IDA IDA: 通过直接分析推断	22732145	GOA
located in nuclear speck	IDA IDA: 通过直接分析推断	12799190	GOA
located in nucleus	IDA IDA: 通过直接分析推断	15632189	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	10066731	GOA
located in vesicle membrane	IDA IDA: 通过直接分析推断	23091060	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DGKQ 蛋白结构

C1_1

DAGK_cat

DAGK_acc

0
200
400
600
800
942 a.a.

蛋白主名

其他名称

diacylglycerol kinase theta

DAG kinase theta

DGKQ 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DGKQ	P52824	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
种属内	DGKQ	P52824	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Retinal Degeneration

Degeneration Of Retina

Gaucher Disease, Type I

Glucocerebrosidase Deficiency	Acid Beta-Glucosidase Deficiency
Gba Deficiency	GD1
Gd I	Gaucher Disease, Noncerebral Juvenile
Gaucher Disease Type 1	Gaucher Disease Type I
Gaucher'S Disease Type I	Gaucher Disease
Gd 1	Non-Cerebral Juvenile Gaucher Disease
GD	Gaucher Disease 1
Adult Non-Neuronopathic Gaucher Disease	Noncerebral Juvenile Gaucher Disease
Type 1 Gaucher Disease	Gaucher Disease, Type 1

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03723	DGKQ Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	DGKQ	VGNC	VGNC:28031
Mus musculus	DGKQ	MGD	MGI:102918
Felis catus	DGKQ	VGNC	VGNC:61463
Rattus norvegicus	DGKQ	RGD	RGD:2320722
Macaca mulatta	DGKQ	VGNC	VGNC:71788
Canis familiaris	DGKQ	VGNC	VGNC:39923

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DGKQ - diacylglycerol kinase theta Gene

关于 DGKQ

功能概要

DGKQ 基因产物(1)

DGKQ 蛋白结构

DGKQ 蛋白互作信息

关联疾病

直系同源

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DGKQ - diacylglycerol kinase theta Gene

关于 DGKQ

功能概要

DGKQ 基因产物(1)

DGKQ 蛋白结构

DGKQ 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z