2. Gene
  3. Ihh - Indian hedgehog Gene

Ihh - Indian hedgehog Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: HHG-2

基因 ID: 16147 | 基因类型: protein coding

关于 Ihh

功能概要

Enables patched binding activity. Involved in several processes, including heart looping; positive regulation of smoothened signaling pathway; and regulation of T cell differentiation. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and positive regulation of biosynthetic process. Located in extracellular matrix. Is expressed in several structures, including alimentary system; egg cylinder; genitourinary system; limb; and skeleton. Used to study Hirschsprung's disease; annular pancreas; and brachydactyly type A1. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; retinopathy of prematurity; and syndactyly type 1. Orthologous to human IHH (Indian Hedgehog signaling molecule). [provided by Alliance of Genome Resources, Apr 2022]

Ihh 基因产物(2)

mRNA Protein Name
NM_001313683.1 NP_001300612.1 indian hedgehog protein isoform 2 precursor
NM_010544.3 NP_034674.2 indian hedgehog protein isoform 1 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables patched binding IPI
IPI: 通过物理相互作用推断
9811851 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10050855 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within bone resorption IDA
IDA: 通过直接分析推断
10208865 MGI
acts upstream of or within branching involved in blood vessel morphogenesis IMP
IMP: 通过突变表型推断
15689378 MGI
acts upstream of or within camera-type eye development IMP
IMP: 通过突变表型推断
18582859 MGI
acts upstream of or within camera-type eye photoreceptor cell fate commitment IMP
IMP: 通过突变表型推断
18582859 MGI
acts upstream of or within cartilage development IMP
IMP: 通过突变表型推断
17191253 MGI
acts upstream of or within cell fate specification IMP
IMP: 通过突变表型推断
18582859 MGI
acts upstream of or within cell maturation IMP
IMP: 通过突变表型推断
15576404 MGI
acts upstream of cell population proliferation IMP
IMP: 通过突变表型推断
16284117 MGI
acts upstream of or within chondrocyte differentiation IDA
IDA: 通过直接分析推断
15951842 MGI
acts upstream of chondrocyte differentiation IMP
IMP: 通过突变表型推断
16284117 MGI
acts upstream of or within chondrocyte differentiation involved in endochondral bone morphogenesis IMP
IMP: 通过突变表型推断
25639508 MGI
acts upstream of or within chondrocyte proliferation IMP
IMP: 通过突变表型推断
16935278 MGI
acts upstream of or within embryo development IMP
IMP: 通过突变表型推断
17881493 MGI
acts upstream of or within embryonic camera-type eye morphogenesis IMP
IMP: 通过突变表型推断
18582859 MGI
acts upstream of or within embryonic digestive tract morphogenesis IMP
IMP: 通过突变表型推断
10821773 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: 通过遗传相互作用推断
20660756 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: 通过突变表型推断
20660756 MGI
acts upstream of or within embryonic pattern specification IMP
IMP: 通过突变表型推断
18582859 MGI
acts upstream of or within embryonic skeletal joint development IMP
IMP: 通过突变表型推断
17191253 MGI
involved in endochondral bone morphogenesis IMP
IMP: 通过突变表型推断
10465785 MGI
acts upstream of or within epithelial cell morphogenesis IMP
IMP: 通过突变表型推断
18582859 MGI
acts upstream of or within epithelial cell-cell adhesion IMP
IMP: 通过突变表型推断
18582859 MGI
acts upstream of or within head morphogenesis IMP
IMP: 通过突变表型推断
16935278 MGI
involved in heart looping IMP
IMP: 通过突变表型推断
11517919 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
17881493 MGI
acts upstream of or within morphogenesis of a branching structure IMP
IMP: 通过突变表型推断
11044404 MGI
acts upstream of or within multicellular organism growth IMP
IMP: 通过突变表型推断
10821773 MGI
involved in negative regulation of T cell differentiation in thymus IMP
IMP: 通过突变表型推断
19109233 MGI
involved in negative regulation of alpha-beta T cell differentiation IMP
IMP: 通过突变表型推断
19109233 MGI
acts upstream of or within negative regulation of chondrocyte differentiation IMP
IMP: 通过突变表型推断
16284117 MGI
acts upstream of or within negative regulation of eye pigmentation IMP
IMP: 通过突变表型推断
17464332 MGI
involved in negative regulation of immature T cell proliferation in thymus IMP
IMP: 通过突变表型推断
19109233 MGI
acts upstream of or within neuron development IMP
IMP: 通过突变表型推断
10821773 MGI
acts upstream of or within ossification IMP
IMP: 通过突变表型推断
11748145 MGI
acts upstream of or within osteoblast differentiation IDA
IDA: 通过直接分析推断
25639508 MGI
acts upstream of or within osteoblast differentiation IGI
IGI: 通过遗传相互作用推断
25639508 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: 通过突变表型推断
14973297 MGI
acts upstream of or within pancreas development IGI
IGI: 通过遗传相互作用推断
11044404 MGI
acts upstream of or within pancreas development IMP
IMP: 通过突变表型推断
10821773 MGI
acts upstream of or within pattern specification process IMP
IMP: 通过突变表型推断
9671585 MGI
involved in positive regulation of T cell differentiation in thymus IMP
IMP: 通过突变表型推断
19109233 MGI
involved in positive regulation of alpha-beta T cell differentiation IMP
IMP: 通过突变表型推断
19109233 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
17191253 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
16284117 MGI
acts upstream of or within positive regulation of collagen biosynthetic process IDA
IDA: 通过直接分析推断
10208865 MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation IMP
IMP: 通过突变表型推断
18582859 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
17881493 MGI
acts upstream of positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
11517919 MGI
acts upstream of or within proteoglycan metabolic process IGI
IGI: 通过遗传相互作用推断
16935278 MGI
acts upstream of or within regulation of growth IGI
IGI: 通过遗传相互作用推断
19590577 MGI
acts upstream of or within retinal pigment epithelium development IMP
IMP: 通过突变表型推断
18582859 MGI
acts upstream of or within skeletal system development IMP
IMP: 通过突变表型推断
16278811 MGI
acts upstream of or within smooth muscle tissue development IMP
IMP: 通过突变表型推断
10821773 MGI
acts upstream of or within smoothened signaling pathway IDA
IDA: 通过直接分析推断
25639508 MGI
acts upstream of or within smoothened signaling pathway IGI
IGI: 通过遗传相互作用推断
19590577 MGI
involved in smoothened signaling pathway IMP
IMP: 通过突变表型推断
11517919 MGI
involved in somite development IMP
IMP: 通过突变表型推断
11517919 MGI
acts upstream of or within vasculature development IMP
IMP: 通过突变表型推断
17881493 MGI
acts upstream of or within vitelline membrane formation IMP
IMP: 通过突变表型推断
17881493 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular matrix IDA
IDA: 通过直接分析推断
11476578 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

indian hedgehog protein

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0338A Rimantadine hydrochloride ≥98.0% 否
HY-B0338 Rimantadine 99.86% 否
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06654 IHH Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ihh NCBI NCBI:3549
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