Ikbkb - inhibitor of kappaB kinase beta Gene

中文名称：kappaB 激酶 β 抑制因子

种属: Mus musculus

同用名: IKK2; IKK-2; IKK[b]; IKKbeta; IKK-beta

关于 Ikbkb

功能概要

该基因编码的蛋白可启动 IkappaB 激酶活性和蛋白磷酸酶结合活性。参与肽基丝氨酸磷酸化和肿瘤坏死因子介导的信号通路。作用于 B 细胞稳态的上游或内部；正调节阳离子通道活性；钠离子转运的正向调节。位于质膜的细胞质侧。 CD40 受体复合体的一部分。以多种结构表达，包括泌尿生殖系统和肌肉组织。用于研究免疫缺陷 15A。该基因与乳腺癌相关的人类直向同源基因；联合免疫缺陷（多种）；皮炎;前列腺癌（多发）；和 2 型糖尿病。与人 IKBKB（核因子 kappa B 激酶亚基 β 抑制剂）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables IkappaB kinase activity and protein Phosphatase binding activity. Involved in peptidyl-serine phosphorylation and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within B cell homeostasis; positive regulation of cation channel activity; and positive regulation of sodium ion transport. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including genitourinary system and musculature. Used to study immunodeficiency 15A. Human ortholog(s) of this gene implicated in breast cancer; combined immunodeficiency (multiple); dermatitis; prostate Cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]