Il1a - interleukin 1 alpha Gene

中文名称：白介素 1α

种属: Mus musculus

同用名: Il-1a

关于 Il1a

功能概要

该基因编码的蛋白可启动细胞因子活性和白细胞介素-1 受体结合活性。参与血管生成的正向调节和血管内皮生长因子产生的正向调节。作用于多个过程的上游或内部，包括细胞表面受体信号通路；参与炎症反应伤口愈合的结缔组织替代；和细胞因子产生的正调节。位于细胞质和细胞外空间。以多种结构表达，包括消化系统；脑;淋巴系统腺体；生殖系统;和呼吸系统。该基因的人类直系同源基因与多种疾病有关，包括法布里病；施尼茨勒综合征；自身免疫性疾病（多种）；血液系统癌症（多发性）；和肺部疾病（多种）。与人 IL1A（白细胞介素 1 α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cytokine activity and interleukin-1 receptor binding activity. Involved in positive regulation of angiogenesis and positive regulation of vascular endothelial growth factor production. Acts upstream of or within several processes, including cell surface receptor signaling pathway; connective tissue replacement involved in inflammatory response wound healing; and positive regulation of cytokine production. Located in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic Cancer (multiple); and lung disease (multiple). Orthologous to human IL1A (interleukin 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]