Il1a - interleukin 1 alpha Gene

中文名称：白介素 1α

种属: Rattus norvegicus

同用名: IL-1F1; IL-1 alpha

关于 Il1a

功能概要

预测该基因编码的蛋白编码的蛋白可启动铜离子结合活性；细胞因子活性；和白细胞介素-1 受体结合活性。参与几个过程，包括角质化；支持细胞屏障建立的负调控；和细胞内信号转导的正调控。位于多个细胞成分中，包括细胞表面；胞质溶胶；和细胞外空间。用于研究间质性肺病。多种疾病的生物标志物，包括子宫内膜炎；肺部疾病（多发）；尿路感染;葡萄膜炎;和精索静脉曲张。该基因的人类直系同源基因与多种疾病有关，包括法布里病；施尼茨勒综合征；自身免疫性疾病（多种）；血液系统癌症（多发性）；和肺部疾病（多种）。与人 IL1A（白细胞介素 1 α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable copper ion binding activity; cytokine activity; and interleukin-1 receptor binding activity. Involved in several processes, including keratinization; negative regulation of establishment of Sertoli cell barrier; and positive regulation of intracellular signal transduction. Located in several cellular components, including cell surface; cytosol; and extracellular space. Used to study interstitial lung disease. Biomarker of several diseases, including endometritis; lung disease (multiple); urinary tract infection; uveitis; and varicocele. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schnitzler syndrome; autoimmune disease (multiple); hematologic Cancer (multiple); and lung disease (multiple). Orthologous to human IL1A (interleukin 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]