ZFPM1 - zinc finger protein, FOG family member 1 Gene

中文名称：锌指蛋白，FOG 家族成员 1

种属: Homo sapiens

同用名: FOG; FOG1; ZNF408; ZNF89A; ZC2HC11A

基因 ID: 161882 | 基因类型: protein coding

关于 ZFPM1

Cytogenetic location: 16q24.2 Genomic coordinates (GRCh38): 16:88,451,769-88,537,031 (from NCBI)

This gene has 5 transcripts (splice variants), 184 orthologues and 1 paralogue. Broad expression in stomach (RPKM 2.3), duodenum (RPKM 1.0) and 20 other tissues.

功能概要

启用 RNA 聚合酶 II 特异性 DNA 结合转录因子结合活性和转录辅阻遏物活性。参与血小板形成；最终红细胞分化的调节；和基因表达的调控。转录抑制复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in platelet formation; regulation of definitive erythrocyte differentiation; and regulation of gene expression. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Apr 2022]

ZFPM1 基因产物(1)

mRNA	Protein	Name
NM_153813.3	NP_722520.2	zinc finger protein ZFPM1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	11675338	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12483298	GOA
enables transcription corepressor activity	IGI IGI: 通过遗传相互作用推断	15920471	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of interleukin-4 production	IDA IDA: 通过直接分析推断	21646796	GOA
involved in negative regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	15920471	GOA
involved in platelet formation	IGI IGI: 通过遗传相互作用推断	11675338	GOA
involved in positive regulation of type II interferon production	IDA IDA: 通过直接分析推断	21646796	GOA
involved in regulation of definitive erythrocyte differentiation	IDA IDA: 通过直接分析推断	15920471	GOA
involved in regulation of definitive erythrocyte differentiation	IMP IMP: 通过突变表型推断	17207461	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of transcription regulator complex	IDA IDA: 通过直接分析推断	15920471	GOA
part of transcription repressor complex	IDA IDA: 通过直接分析推断	15920471	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZFPM1 蛋白结构

zf-C2H2_6

zf-H2C2_2

zf-C2H2_6

0
200
400
600
800
1006 a.a.

蛋白主名

其他名称

zinc finger protein ZFPM1

FOG-1

ZFPM1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ZFPM1	Q8IX07	GSK3B	Homo sapiens	P49841	Anti Tag CoIP	21988832
种属内	ZFPM1	Q8IX07	RBBP4	Homo sapiens	Q09028	Pull Down	21047798

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Thrombocytopenia 1

Xlt	THC1
Thrombocytopenia, X-Linked	Thrombocytopenia, X-Linked, Intermittent
X-Linked Thrombocytopenia	X-Linked Thrombocytopenia With Normal Platelets
Thc	Thrombocytopenia, X-Linked, 1
Thrombocytopenia X-Linked	Thrombocytopenia X-Linked 1

Congenital Dyserythropoietic Anemia

Congenital Dyshaematopoietic Anaemia	Dyserythropoietic Anemia, Congenital
Cda	Anemia, Dyserythropoietic, Congenital
Anemia Dyserythropoietic Congenital	Cda - [Congenital Dyserythropoietic Anaemia]
Dyserythropoietic Dyshaematopoietic Congenital Anaemia	Dyshaematopoietic Anaemia
Dyserythropoietic Anaemia

Thrombocytopenia With Beta-Thalassemia, X-Linked

XLTT	Thrombocytopenia, Platelet Dysfunction, Hemolysis, And Imbalanced Globin Synthesis
Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome	Gata1-Related X-Linked Cytopenia
X-Linked Thrombocytopenia With Beta-Thalassemia	Thrombocytopenia Platelet Dysfunction Hemolysis And Imbalanced Globin Synthesis

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy	Fevr
Criswick-Schepens Syndrome	Exudative Vitreoretinopathy, Familial
Vitreoretinopathy, Exudative )	Exudative Vitreoretinopathy 1

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Retinitis Pigmentosa 56

RP56	Maculopathy, Impg2-Related
MACLP-IMPG2	Retinitis Pigmentosa, Type 56

Cutaneous Porphyria

Porphyria, Erythropoietic

Erythropoietic Porphyria

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Persistent Hyperplastic Primary Vitreous

Congenital Retinal Detachment	Ncrna Disease
Non-Syndromic Congenital Retinal Non-Attachment	Pfvs
Phpv	Persistent Fetal Vasculature Syndrome

Myelofibrosis

Primary Myelofibrosis	Agnogenic Myeloid Metaplasia
Idiopathic Myelofibrosis	Myeloid Metaplasia
Myelofibrosis With Myeloid Metaplasia	Osteomyelofibrosis
Megakaryocytic Myelosclerosis	Myelosclerosis
Chronic Idiopathic Myelofibrosis	Myelofibrosis, Idiopathic
Myelofibrosis With Myeloid Metaplasia, Somatic	Myelofibrosis, Somatic
Aleukemic Myelosis	Bone Marrow Fibrosis
MYELOF	MMM
Agnogenic Myeloid Metaplasia With Myelofibrosis	Ammm
Myelosclerosis With Myeloid Metaplasia	Myelofibrosis Nos

Myeloproliferative Syndrome, Transient

Transient Abnormal Myelopoiesis	Transient Myeloproliferative Syndrome
Transient Myeloproliferative Disease	Mst
Tam	Leukemia, Transient, Of Down Syndrome
Tmd	Leukemia, Transient
Transient Leukemia	Transient Leukemia Of Down Syndrome

Acute Erythroid Leukemia

Acute Erythroleukemia	Di Guglielmo'S Syndrome
Aml M6	Acute Myeloid Leukemia Fab-M6
Acute Myeloid Leukemia M6	Erythroleukemia
Aml-M6	Acute Erythroleukemia M6a Subtype
Acute Erythroleukemia M6b Subtype	Di Guglielmo Syndrome
Acute Myeloid Leukemia, M6 Type	Acute Erythroblastic Leukemia
Acute Erythroleukemia - M6a Subtype	Acute Erythroleukemia - M6b Subtype
Acute Erythraemia And Erythroleukaemia	Acute Erythroid Leukaemia Without Mention Of Remission
Erythraemia	Erythraemic Myelosis
Erythroleukaemia	Acute Erythraemic Myelosis
Acute Erythraemia

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16048	ZFPM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ZFPM1	VGNC	VGNC:53486
Mus musculus	ZFPM1	MGD	MGI:1095400
Bos taurus	ZFPM1	VGNC	VGNC:58429
Rattus norvegicus	ZFPM1	RGD	RGD:1582810
Macaca mulatta	ZFPM1	VGNC	VGNC:104765

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ZFPM1 - zinc finger protein, FOG family member 1 Gene

关于 ZFPM1

功能概要

ZFPM1 基因产物(1)

ZFPM1 蛋白结构

ZFPM1 蛋白互作信息

关联疾病

直系同源

热门区域

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ZFPM1 - zinc finger protein, FOG family member 1 Gene

关于 ZFPM1

功能概要

ZFPM1 基因产物(1)

ZFPM1 蛋白结构

ZFPM1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z