Insr - insulin receptor Gene

中文名称：胰岛素受体

种属: Mus musculus

同用名: IR; IR-A; IR-B; CD220; 4932439J01Rik; D630014A15Rik

关于 Insr

功能概要

该基因编码跨膜信号蛋白的受体酪氨酸激酶家族成员，在细胞分化、生长和代谢中起重要作用。编码的前原蛋白经过蛋白水解加工产生 α 和 β 链，形成二硫键连接的异源二聚体，后者进而同二聚化形成成熟的功能性受体。缺乏编码蛋白的小鼠会出现严重的高血糖症和高酮血症，并在出生后几天内死于糖尿病酮症酸中毒。 [RefSeq 提供，2016 年 8 月]

This gene encodes a member of the receptor tyrosine kinase family of transmembrane signaling proteins that play important roles in cell differentiation, growth and metabolism. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta chains that form a disulfide-linked heterodimer which, in turn homodimerizes to form a mature, functional receptor. Mice lacking the encoded protein develop severe hyperglycemia and hyperketonemia, and die within a couple of days after birth as a result of diabetic ketoacidosis. [provided by RefSeq, Aug 2016]