2. Gene
  3. Itgb6 - integrin beta 6 Gene

Itgb6 - integrin beta 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: 2210409C20Rik; 4831415H04Rik

基因 ID: 16420 | 基因类型: protein coding

关于 Itgb6

功能概要

Enables Integrin binding activity. Involved in cell adhesion mediated by Integrin and transforming growth factor beta production. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including animal organ development; hard palate development; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in external side of plasma membrane. Part of Integrin alphav-beta6 complex. Is expressed in several structures, including diaphragm; gut; limb; metanephros; and vertebral axis musculature. Used to study asthma and pulmonary emphysema. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1H. Orthologous to human ITGB6 (Integrin subunit beta 6). [provided by Alliance of Genome Resources, Apr 2022]

Itgb6 基因产物(2)

mRNA Protein Name
NM_001159564.1 NP_001153036.1 integrin beta-6 precursor
NM_021359.3 NP_067334.1 integrin beta-6 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables integrin binding IPI
IPI: 通过物理相互作用推断
8601592 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Langerhans cell differentiation IGI
IGI: 通过遗传相互作用推断
19118215 MGI
acts upstream of or within bone development IMP
IMP: 通过突变表型推断
30467097 MGI
acts upstream of or within bronchiole development IDA
IDA: 通过直接分析推断
12634787 MGI
acts upstream of or within bronchiole development IMP
IMP: 通过突变表型推断
12634787 MGI
involved in cell adhesion mediated by integrin IDA
IDA: 通过直接分析推断
24681597 MGI
acts upstream of or within cell morphogenesis IMP
IMP: 通过突变表型推断
17641300 MGI
acts upstream of or within cell-matrix adhesion IMP
IMP: 通过突变表型推断
23264742 MGI
acts upstream of or within cellular response to ionizing radiation IDA
IDA: 通过直接分析推断
17916808 MGI
acts upstream of or within cytokine production involved in inflammatory response IMP
IMP: 通过突变表型推断
30467097 MGI
acts upstream of or within enamel mineralization IMP
IMP: 通过突变表型推断
23264742 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
12634787 MGI
acts upstream of or within negative effect gene expression IMP
IMP: 通过突变表型推断
23264742 MGI
acts upstream of or within hard palate development IGI
IGI: 通过遗传相互作用推断
19118215 MGI
acts upstream of or within immune response IGI
IGI: 通过遗传相互作用推断
19118215 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
15963261 MGI
acts upstream of or within lung alveolus development IDA
IDA: 通过直接分析推断
12634787 MGI
acts upstream of or within lung alveolus development IMP
IMP: 通过突变表型推断
12634787 MGI
acts upstream of or within phospholipid homeostasis IMP
IMP: 通过突变表型推断
17641300 MGI
acts upstream of or within response to virus IGI
IGI: 通过遗传相互作用推断
30952606 MGI
acts upstream of or within response to wounding IDA
IDA: 通过直接分析推断
24319098 MGI
acts upstream of or within skin development IMP
IMP: 通过突变表型推断
12634787 MGI
acts upstream of or within surfactant homeostasis IMP
IMP: 通过突变表型推断
17641300 MGI
involved in transforming growth factor beta production IDA
IDA: 通过直接分析推断
24681597 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
30952606 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
12634787 MGI
acts upstream of or within wound healing IMP
IMP: 通过突变表型推断
30500364 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
16710477 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
9553049 MGI
part of integrin alphav-beta6 complex IDA
IDA: 通过直接分析推断
24681597 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

integrin beta-6

重组 Itgb6 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77723 Integrin alpha V beta 6 Protein, Mouse (HEK293, His) P43406 (F31-V988)&Q9Z0T9 (G22-N706) ≥95%
HY-P700769 ITGB6 Protein, Mouse (HEK293, His) Q9Z0T9 (G22-N706) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-164957 SGN-B6A Inhibitor / 否
HY-RS06970 ITGB6 Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990764 Sigvotatug Ligand 99.67% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Itgb6 NCBI NCBI:3694
Macaca mulatta Itgb6 NCBI NCBI:700454
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