GADD45A - growth arrest and DNA damage inducible alpha Gene

中文名称：生长停滞和 DNA 损伤诱导 alpha

种属: Homo sapiens

同用名: DDIT1; GADD45

基因 ID: 1647 | 基因类型: protein coding

关于 GADD45A

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:67,685,201-67,688,334 (from NCBI)

This gene has 7 transcripts (splice variants), 261 orthologues and 2 paralogues. Broad expression in liver (RPKM 72.1), kidney (RPKM 57.9) and 23 other tissues.

功能概要

该基因是一组基因的成员，其转录水平在应激生长停滞条件和 DNA 损伤剂处理后增加。由该基因编码的蛋白质通过 MTK1/MEKK4 激酶介导 p38/JNK 通路的激活来响应环境压力。该基因的 DNA 损伤诱导转录由 p53 依赖性和非依赖性机制介导。已为该基因发现编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2010 年 12 月]

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

GADD45A 基因产物(3)

mRNA	Protein	Name
NM_001199741.2	NP_001186670.1	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 2
NM_001199742.2	NP_001186671.1	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 3
NM_001924.4	NP_001915.1	growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables kinase binding	IPI IPI: 通过物理相互作用推断	20460379	GOA
enables protein binding	IDA IDA: 通过直接分析推断	20460379	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12716909	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	20460379	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	20460379	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to ionizing radiation	IMP IMP: 通过突变表型推断	20160708	GOA
involved in cellular response to mechanical stimulus	IEP IEP: 通过表达模式推断	19593445	GOA
involved in negative regulation of blood vessel endothelial cell migration	IMP IMP: 通过突变表型推断	23329839	GOA
involved in negative regulation of peptidyl-serine phosphorylation of STAT protein	IMP IMP: 通过突变表型推断	23329839	GOA
involved in negative regulation of protein serine/threonine kinase activity	IMP IMP: 通过突变表型推断	23329839	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	23329839	GOA
involved in positive regulation of JNK cascade	IDA IDA: 通过直接分析推断	9827804	GOA
involved in positive regulation of apoptotic process	IDA IDA: 通过直接分析推断	9827804	GOA
involved in positive regulation of p38MAPK cascade	IDA IDA: 通过直接分析推断	9827804	GOA
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: 通过突变表型推断	20160708	GOA
involved in signal transduction in response to DNA damage	IMP IMP: 通过突变表型推断	20160708	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	9827804	GOA
located in nucleus	IDA IDA: 通过直接分析推断	9827804	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GADD45A 蛋白结构

Ribosomal_L7Ae

0
100
165 a.a.

蛋白主名

其他名称

growth arrest and DNA damage-inducible protein GADD45 alpha

DDIT-1

GADD45A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GADD45A	P24522	CNOT9	Homo sapiens	Q92600-3	Validated Y2H	32296183
种属内	GADD45A	P24522	NUCB2	Homo sapiens	P80303	Anti Tag CoIP	21988832
种属内	GADD45A	P24522	SH3GLB1	Homo sapiens	Q9Y371	Y2H	21988832
种属内	GADD45A	P24522	PCNA	Homo sapiens	P12004	Lumier	32814053
种属内	GADD45A	P24522	GADD45GIP1	Homo sapiens	Q8TAE8	Pull Down	12716909
种属内	GADD45A	P24522	AICDA	Homo sapiens	Q9GZX7	Anti Tag CoIP	21722948
种属间	GADD45A	P24522	Aicda	Mus musculus	Q9WVE0	Anti Tag CoIP	23820005
种属内	GADD45A	P24522	PARVG	Homo sapiens	Q9HBI0	Validated Y2H	32296183
种属内	GADD45A	P24522	DCTN2	Homo sapiens	Q13561	Validated Y2H	32296183
种属内	GADD45A	P24522	DCTN2	Homo sapiens	Q13561	Y2H Pooling	16189514
种属内	GADD45A	P24522	DCTN2	Homo sapiens	Q13561	Y2H	21988832
种属内	GADD45A	P24522	ERCC5	Homo sapiens	P28715	Anti Bait CoIP	17268471
种属内	GADD45A	P24522	ERCC5	Homo sapiens	P28715	Pull Down	17268471

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GADD45A 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70326	GADD45A/DDDIT-1 Protein, Human (His)	P24522 (M1-R165)	≥95%

关联疾病

疾病名称

别名

Ataxia-Telangiectasia

Ataxia Telangiectasia	Louis-Bar Syndrome
AT	At1
Ataxia-Telangiectasia Syndrome	Ataxia - Telangiectasia Variant
Boder-Sedgwick Syndrome	Louis Bar Syndrome
Cerebello-Oculocutaneous Telangiectasia	Immunodeficiency With Ataxia Telangiectasia
A-T	Ataxia Telangiectasia Syndrome
Atm	Telangiectasia, Cerebello-Oculocutaneous
Ataxia-Telangiectasia Variant

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Ureteral Obstruction

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Li-Fraumeni Syndrome

Sarcoma Family Syndrome Of Li And Fraumeni	Sbla Syndrome
LFS	Li-Fraumeni Familiar Cancer Susceptibility Syndrome
Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome	Lfs1
Li Fraumeni Syndrome	Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome
Lfl	Sbla Syndrome Li-Fraumeni-Like Syndrome
Li-Fraumeni Syndrome 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-10587	BIX-01294		98.75%	否
HY-108239	BIX-01294 trihydrochloride		/	否
HY-RS05229	GADD45A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	GADD45A	VGNC	VGNC:80215
Canis familiaris	GADD45A	VGNC	VGNC:41069
Bos taurus	GADD45A	VGNC	VGNC:29206
Macaca mulatta	GADD45A	VGNC	VGNC:106369
Rattus norvegicus	GADD45A	RGD	RGD:2654
Mus musculus	GADD45A	MGD	MGI:107799
Others	GADD45A	NCBI

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