2. Gene
  3. ADGRA3 - adhesion G protein-coupled receptor A3 Gene

ADGRA3 - adhesion G protein-coupled receptor A3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：粘附 G 蛋白偶联受体 A3

种属: Homo sapiens

同用名: PGR21; TEM5L; GPR125

基因 ID: 166647 | 基因类型: protein coding

关于 ADGRA3

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:22,387,376-22,516,066 (from NCBI)

This gene has 13 transcripts (splice variants), 204 orthologues, 42 paralogues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 9.5), liver (RPKM 6.2) and 24 other tissues.

功能概要

该基因编码 G 蛋白偶联受体超家族的成员。这种膜蛋白可能通过与果蝇圆盘大肿瘤抑制基因的人类同系物相互作用而在肿瘤血管生成中发挥作用。该基因被映射到 4 号染色体的一个候选区域，该区域可能与双相情感障碍和精神分裂症有关。[RefSeq 提供，2012 年 10 月]

This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]

ADGRA3 基因产物(1)

mRNA Protein Name
NM_145290.4 NP_660333.2 adhesion G protein-coupled receptor A3 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15021905 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADGRA3 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (85 - 141)

I-set

I-set: Immunoglobulin I-set domain (247 - 340)

HRM

HRM: Hormone receptor domain (361 - 416)

GPS

GPS: GPCR proteolysis site, GPS, motif (702 - 744)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (765 - 1018)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1321 a.a.
蛋白主名 其他名称

adhesion G protein-coupled receptor A3

G-protein coupled receptor 125

关联疾病

疾病名称 别名
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Spermatocytoma

Spermatocytic Seminoma
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism

Undescended Testicle

Undescended Testis

Cryptorchism

Undescended Testicles

CRYPTO

Impaired Testicular Descent

Cryptosporidiosis

Retained Testis

Unilateral Cryptorchidism

Unilateral Undescended Testis

Nondescent Unilateral Testicle

Unilateral Cryptorchism

Ectopic Testis, Unilateral

Bilateral Cryptorchidism

Bilateral Cryptorchism

Bilateral Nondescent Testicle

Bilateral Undescended Testes

Bilateral Ectopic Testes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00344 ADGRA3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ADGRA3 VGNC VGNC:59629
Rattus norvegicus ADGRA3 RGD RGD:1304914
Bos taurus ADGRA3 VGNC VGNC:25657
Macaca mulatta ADGRA3 VGNC VGNC:82099
Canis familiaris ADGRA3 VGNC VGNC:37633
Mus musculus ADGRA3 MGD MGI:1917943
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