Map2k1 - mitogen activated protein kinase kinase 1 Gene

中文名称：有丝分裂原活化蛋白激酶激酶 1

种属: Rattus norvegicus

同用名: Mek1

关于 Map2k1

功能概要

该基因编码的蛋白可启动 ATP 绑定活动； MAP激酶激酶活性；和酶结合活性。参与多个过程，包括囊泡定位的建立；基因表达的调节；和细胞内信号转导的调节。在 Ras 蛋白信号转导的正调节上游或正调节内起作用。位于几种细胞成分中，包括树突细胞质；核周;和细胞质的核周区。在谷氨酸能突触和突触后密度中活跃。与微管共定位。用于研究白内障和前列腺癌。该基因的人类直系同源物与癌症有关（多个）；心面皮肤综合征 3；高级别神经胶质瘤；和骨质疏松症。与人 MAP2K1（丝裂原活化蛋白激酶激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity; MAP kinase kinase activity; and Enzyme binding activity. Involved in several processes, including establishment of vesicle localization; regulation of gene expression; and regulation of intracellular signal transduction. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in several cellular components, including dendrite cytoplasm; perikaryon; and perinuclear region of cytoplasm. Is active in glutamatergic synapse and postsynaptic density. Colocalizes with microtubule. Used to study cataract and prostate adenocarcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]