Map2k1 - mitogen activated protein kinase kinase 1 Gene

中文名称：有丝分裂原活化蛋白激酶激酶 1

种属: Rattus norvegicus

同用名: Mek1

基因 ID: 170851 | 基因类型: protein coding

关于 Map2k1

Primary_assembly 8: 64,683,449-64,755,147 reverse strand.mRatBN7.2:CM026981.1

This gene has 5 transcripts (splice variants), 211 orthologues, 8 paralogues and is associated with 38 phenotypes. Biased expression in Brain (RPKM 58.), Muscle (RPKM 31.3) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 ATP 绑定活动； MAP激酶激酶活性；和酶结合活性。参与多个过程，包括囊泡定位的建立；基因表达的调节；和细胞内信号转导的调节。在 Ras 蛋白信号转导的正调节上游或正调节内起作用。位于几种细胞成分中，包括树突细胞质；核周;和细胞质的核周区。在谷氨酸能突触和突触后密度中活跃。与微管共定位。用于研究白内障和前列腺癌。该基因的人类直系同源物与癌症有关（多个）；心面皮肤综合征 3；高级别神经胶质瘤；和骨质疏松症。与人 MAP2K1（丝裂原活化蛋白激酶激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity; MAP kinase kinase activity; and Enzyme binding activity. Involved in several processes, including establishment of vesicle localization; regulation of gene expression; and regulation of intracellular signal transduction. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in several cellular components, including dendrite cytoplasm; perikaryon; and perinuclear region of cytoplasm. Is active in glutamatergic synapse and postsynaptic density. Colocalizes with microtubule. Used to study cataract and prostate adenocarcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Map2k1 基因产物(1)

mRNA	Protein	Name
NM_031643.4	NP_113831.1	dual specificity mitogen-activated protein kinase kinase 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	7611406	RGD
enables MAP kinase kinase activity	IDA IDA: 通过直接分析推断	7611406	RGD
enables mitogen-activated protein kinase kinase kinase binding	IDA IDA: 通过直接分析推断	7565670	RGD
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: 通过物理相互作用推断	16006144	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	16272159	RGD
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	15917294	RGD
enables protein-containing complex binding	IPI IPI: 通过物理相互作用推断	15917294	RGD
enables small GTPase binding	IPI IPI: 通过物理相互作用推断	7935430	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Golgi inheritance	IMP IMP: 通过突变表型推断	9458043	RGD
involved in melanosome transport	IDA IDA: 通过直接分析推断	15753041	RGD
involved in negative regulation of gene expression	IGI IGI: 通过遗传相互作用推断	28947594	RGD
involved in negative regulation of homotypic cell-cell adhesion	IMP IMP: 通过突变表型推断	17183546	RGD
involved in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IGI IGI: 通过遗传相互作用推断	15459207	RGD
involved in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IMP IMP: 通过突变表型推断	15459207	RGD
involved in neuron differentiation	IMP IMP: 通过突变表型推断	17202850	RGD
involved in neuron projection morphogenesis	IMP IMP: 通过突变表型推断	17202850	RGD
involved in positive regulation of ATP biosynthetic process	IGI IGI: 通过遗传相互作用推断	15459207	RGD
involved in positive regulation of ATP biosynthetic process	IMP IMP: 通过突变表型推断	15459207	RGD
involved in positive regulation of GTPase activity	IMP IMP: 通过突变表型推断	17183546	RGD
involved in positive regulation of MAPK cascade	IDA IDA: 通过直接分析推断	7935430	RGD
acts upstream of or within positive regulation of Ras protein signal transduction	IMP IMP: 通过突变表型推断	19029245	RGD
involved in positive regulation of autophagy	IDA IDA: 通过直接分析推断	26581593	RGD
involved in positive regulation of cell migration	IMP IMP: 通过突变表型推断	17183546	RGD
involved in positive regulation of gene expression	IGI IGI: 通过遗传相互作用推断	15459207	RGD
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	15459207	RGD
involved in positive regulation of muscle contraction	IGI IGI: 通过遗传相互作用推断	15459207	RGD
involved in positive regulation of muscle contraction	IMP IMP: 通过突变表型推断	15459207	RGD
involved in positive regulation of transcription elongation by RNA polymerase II	IMP IMP: 通过突变表型推断	18086894	RGD
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	7565670	RGD
involved in regulation of ERK1 and ERK2 cascade	IDA IDA: 通过直接分析推断	26581593	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	EXP EXP: 通过实验结果推断	12202034	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: 通过直接分析推断	12202034	RGD
involved in regulation of vascular associated smooth muscle contraction	IMP IMP: 通过突变表型推断	10198244	RGD
involved in response to axon injury	IMP IMP: 通过突变表型推断	15737734	RGD
involved in response to glucocorticoid	IDA IDA: 通过直接分析推断	11872750	RGD
involved in response to oxidative stress	IDA IDA: 通过直接分析推断	16481589	RGD
involved in triglyceride homeostasis	IDA IDA: 通过直接分析推断	26581593	RGD
involved in vesicle transport along microtubule	IDA IDA: 通过直接分析推断	15753041	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in axon	IDA IDA: 通过直接分析推断	9714150	RGD
located in cell cortex	IDA IDA: 通过直接分析推断	16272159	RGD
located in dendrite	IDA IDA: 通过直接分析推断	10465442	RGD
located in dendrite cytoplasm	IDA IDA: 通过直接分析推断	9714150	RGD
is active in glutamatergic synapse	EXP EXP: 通过实验结果推断	12202034	RGD
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	12202034	RGD
located in microtubule	IDA IDA: 通过直接分析推断	10465442	RGD
located in perikaryon	IDA IDA: 通过直接分析推断	9714150	RGD
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	12876277	RGD
is active in postsynaptic density	IDA IDA: 通过直接分析推断	7478291	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Map2k1 蛋白结构

PKc_MEK1

0
100
200
300
393 a.a.

蛋白主名

其他名称

dual specificity mitogen-activated protein kinase kinase 1

ERK activator kinase 1	MAP kinase kinase 1
MAP kinase/Erk kinase 1	MAPK/ERK kinase 1
MAPKK 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-136848	SM1-71	Inhibitor	96.09%	否
HY-RS08033	MAP2K1 Human Pre-designed siRNA Set A		/	否
HY-RS08034	Map2k1 Mouse Pre-designed siRNA Set A		/	否
HY-RS08035	Map2k1 Rat Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Map2k1	NCBI	NCBI:5604
Mus musculus	Map2k1	NCBI	NCBI:26395

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Map2k1 - mitogen activated protein kinase kinase 1 Gene

关于 Map2k1

功能概要

Map2k1 基因产物(1)

Map2k1 蛋白结构

直系同源

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Map2k1 - mitogen activated protein kinase kinase 1 Gene

关于 Map2k1

功能概要

Map2k1 基因产物(1)

Map2k1 蛋白结构

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z