Map2k1 - mitogen-activated protein kinase kinase 1 Gene

中文名称：丝裂原活化蛋白激酶激酶 1

种属: Mus musculus

同用名: Mek1; MEKK1; MAPKK1; Prkmk1

关于 Map2k1

功能概要

该基因编码的蛋白可启动 MAP 激酶激酶活性。作用于多个过程的上游或内部，包括 ERK1 和 ERK2 级联；动物器官发育；和神经发生。预计位于几种细胞成分中，包括树突细胞质；核周;和细胞质的核周区。预测与微管共定位。以多种结构表达，包括消化系统；早孕;泌尿生殖系统；神经系统;和感觉器官。用于研究心面皮肤综合征。该基因的人类直系同源物与癌症有关（多个）；心面皮肤综合征 3；高级别神经胶质瘤；和骨质疏松症。与人 MAP2K1（丝裂原活化蛋白激酶激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables MAP kinase kinase activity. Acts upstream of or within several processes, including ERK1 and ERK2 cascade; animal organ development; and neurogenesis. Predicted to be located in several cellular components, including dendrite cytoplasm; perikaryon; and perinuclear region of cytoplasm. Predicted to colocalize with microtubule. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study cardiofaciocutaneous syndrome. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]