1. Gene
  2. Slc6a5 - solute carrier family 6 member 5 Gene

Slc6a5 - solute carrier family 6 member 5 Gene

中文名称:溶质载体家族 6 成员 5

种属: Rattus norvegicus

同用名: GLYT2

基因 ID: 171148 | 基因类型: protein coding

关于 Slc6a5

Primary_assembly 1: 99,645,389-99,697,010 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 210 orthologues, 20 paralogues and is associated with 7 phenotypes. Restricted expression toward (RPKM 649.2).

功能概要

该基因编码的蛋白可启动甘氨酸跨膜转运蛋白活性。参与甘氨酸转运和神经递质摄取。位于致密的核心颗粒和核内体中。在甘氨酸能突触中活跃。是突触前膜的组成部分。该基因的人类直向同源基因与 hyperekplexia 3 相关。与人类 SLC6A5(溶质载体家族 6 成员 5)直向同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables glycine transmembrane transporter activity. Involved in glycine transport and neurotransmitter uptake. Located in dense core granule and endosome. Is active in glycinergic synapse. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in hyperekplexia 3. Orthologous to human SLC6A5 (solute carrier family 6 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a5 基因产物(1)

mRNA Protein Name
NM_203334.1 NP_976079.1 sodium- and chloride-dependent glycine transporter 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glycine transmembrane transporter activity IDA
IDA: 通过直接分析推断
8226790 RGD
enables glycine:sodium symporter activity IDA
IDA: 通过直接分析推断
8226790 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in glycine transport IDA
IDA: 通过直接分析推断
8226790 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dense core granule IDA
IDA: 通过直接分析推断
12091465 RGD
located in endosome IDA
IDA: 通过直接分析推断
12091465 RGD
is active in glycinergic synapse IDA
IDA: 通过直接分析推断
7751957 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
7751957 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Slc6a5 蛋白结构

SLC6sbd_GlyT2

SLC6sbd_GlyT2: cd11499 (192 - 788)

  • 0
  • 200
  • 400
  • 600
  • 799 a.a.
蛋白主名 其他名称

sodium- and chloride-dependent glycine transporter 2

glyT-2

glycine transporter 2

solute carrier family 6 (neurotransmitter transporter), member 5

solute carrier family 6 (neurotransmitter transporter, glycine), member 5

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc6a5 NCBI NCBI:9152