2. Gene
  3. Smad5 - SMAD family member 5 Gene

Smad5 - SMAD family member 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Dwf-C; Madh5; MusMLP; 1110051M15Rik

基因 ID: 17129 | 基因类型: protein coding

关于 Smad5

功能概要

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in SMAD protein signal transduction; cellular response to BMP stimulus; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; osteoblast fate commitment; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; egg cylinder; embryo mesenchyme; and genitourinary system. Orthologous to human SMAD5 (Smad Family member 5). [provided by Alliance of Genome Resources, Apr 2022]

Smad5 基因产物(3)

mRNA Protein Name
NM_001164041.1 NP_001157513.1 mothers against decapentaplegic homolog 5
NM_001164042.1 NP_001157514.1 mothers against decapentaplegic homolog 5
NM_008541.3 NP_032567.1 mothers against decapentaplegic homolog 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
22964636 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
18692037 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
11729207 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12370310 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within BMP signaling pathway IDA
IDA: 通过直接分析推断
18590716 MGI
acts upstream of or within BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
19224984 MGI
involved in BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
19252488 MGI
involved in SMAD protein signal transduction IGI
IGI: 通过遗传相互作用推断
19252488 MGI
acts upstream of or within bone development IGI
IGI: 通过遗传相互作用推断
19224984 MGI
acts upstream of or within cardiac muscle contraction IMP
IMP: 通过突变表型推断
17456754 MGI
acts upstream of or within cartilage development IGI
IGI: 通过遗传相互作用推断
19224984 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: 通过直接分析推断
19103752 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: 通过突变表型推断
15591122 MGI
acts upstream of or within germ cell development IMP
IMP: 通过突变表型推断
11404080 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
22964636 MGI
acts upstream of or within osteoblast fate commitment IGI
IGI: 通过遗传相互作用推断
15150273 MGI
acts upstream of or within positive regulation of osteoblast differentiation IGI
IGI: 通过遗传相互作用推断
15150273 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15557274 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
20843790 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
18776146 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
11376112 MGI
involved in ureteric bud development IEP
IEP: 通过表达模式推断
14656760 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19103752 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12151307 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

mothers against decapentaplegic homolog 5

MAD homolog 5

Smad 5

dwarfin-C

mSmad5

mothers against DPP homolog 5

重组 Smad5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74539 SMAD5 Protein, Mouse (sf9, His-GST) P97454 (T2-S465) ≥95%
HY-P74540 SMAD5 Protein, Mouse (sf9) P97454 (T2-S465) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13396 SMAD5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Smad5 NCBI NCBI:4090
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