Mc4r - melanocortin 4 receptor Gene

中文名称：黑皮质素 4 受体

种属: Mus musculus

同用名: Pkcp; Mc4-r

关于 Mc4r

功能概要

该基因编码黑皮质素受体家族的一个成员。黑皮质素受体是跨膜 G 蛋白偶联受体，它对小肽激素有反应，并表现出多种功能和组织类型定位。作为中枢神经黑皮质素系统的一部分，编码的蛋白质与促黑素细胞激素或刺豚鼠相关蛋白竞争性结合，以调节能量稳态。该基因的破坏会促进摄食过多和肥胖，并与胆固醇水平升高和胰岛素抵抗有关。 [RefSeq 提供，2012 年 12 月]

This gene encodes a member of the Melanocortin Receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide Hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis. Disruption of this gene promotes hyperphagia and obesity, and is associated with increased Cholesterol levels and Insulin resistance. [provided by RefSeq, Dec 2012]