2. Gene
  3. Mertk - MER proto-oncogene tyrosine kinase Gene

Mertk - MER proto-oncogene tyrosine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Eyk; Mer; Nyk; nmf12

基因 ID: 17289 | 基因类型: protein coding

关于 Mertk

功能概要

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within several processes, including animal organ development; neutrophil clearance; and protein kinase B signaling. Predicted to be located in several cellular components, including extracellular space; photoreceptor outer segment; and rhabdomere. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; immune system; and retina. Human ortholog(s) of this gene implicated in retinitis pigmentosa 38. Orthologous to human MERTK (Mer proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Mertk 基因产物(1)

mRNA Protein Name
NM_008587.2 NP_032613.1 tyrosine-protein kinase Mer precursor
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within apoptotic cell clearance IDA
IDA: 通过直接分析推断
29440417 MGI
acts upstream of or within apoptotic cell clearance IGI
IGI: 通过遗传相互作用推断
18159085 MGI
acts upstream of or within apoptotic cell clearance IMP
IMP: 通过突变表型推断
17442946 MGI
involved in apoptotic cell clearance IMP
IMP: 通过突变表型推断
18159085 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
15650770 MGI
acts upstream of lymphocyte activation IGI
IGI: 通过遗传相互作用推断
11452127 MGI
acts upstream of or within natural killer cell differentiation IGI
IGI: 通过遗传相互作用推断
16751775 MGI
acts upstream of or within negative regulation of cytokine production IGI
IGI: 通过遗传相互作用推断
23878224 MGI
acts upstream of or within negative regulation of lymphocyte activation IGI
IGI: 通过遗传相互作用推断
11452127 MGI
acts upstream of or within neutrophil clearance IGI
IGI: 通过遗传相互作用推断
23878224 MGI
acts upstream of or within platelet activation IMP
IMP: 通过突变表型推断
15650770 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: 通过遗传相互作用推断
15650770 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: 通过突变表型推断
21052544 MGI
acts upstream of or within secretion by cell IMP
IMP: 通过突变表型推断
15650770 MGI
acts upstream of or within spermatogenesis IGI
IGI: 通过遗传相互作用推断
10227296 MGI
acts upstream of or within substrate adhesion-dependent cell spreading IMP
IMP: 通过突变表型推断
15650770 MGI
acts upstream of or within vagina development IGI
IGI: 通过遗传相互作用推断
18393392 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine-protein kinase Mer

Tyro 12

c-mer proto-oncogene tyrosine kinase

proto-oncogene c-Mer

proto-oncogene tyrosine-protein kinase Mer

receptor tyrosine kinase MerTK

重组 Mertk 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73289 Mer Protein, Mouse (sf9, His-GST) Q60805 (E573-Y867) ≥95%
HY-P73820 Mer Protein, Mouse (HEK293, Fc) Q60805 (M1-F498) ≥95%
HY-P700446 MERTK Protein, Mouse (HEK293, His) Q60805 (G19-M497) ≥95%

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-15514 Merestinib Inhibitor 99.99% Phase 2
HY-101549 MRX-2843 Inhibitor 99.70% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2
Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12344 UNC2025 Inhibitor 99.83% 否
HY-125510 UNC2541 Inhibitor 99.71% 否
HY-12344A UNC2025 hydrochloride Inhibitor 99.87% 否
HY-132200 UNC5293 Inhibitor 95.07% 否
HY-117548 UNC1062 Inhibitor 99.48% 否
HY-124502 UNC4203 Inhibitor 99.80% 否
HY-131909 CJ-2360 Inhibitor / 否
HY-162406 UNC8969 / 否
HY-162940 MerTK/Axl-IN-1 Inhibitor / 否
HY-169208 MerTK-IN-1 Inhibitor / 否
HY-RS08340 MERTK Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-101549A MRX-2843 hydrochloride Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mertk NCBI NCBI:10461
Macaca fascicularis Mertk NCBI NCBI:102143798
Rattus norvegicus Mertk NCBI NCBI:65037
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z