2. Protein Tyrosine Kinase/RTK
  3. TAM Receptor
  4. UNC8969

UNC8969 (compound 43) 是 MERTK/AXL 双重抑制剂，对 MERTK 的IC50 为 1.1±0.8 nM，对 AXL 为5.3±2.7 nM。在小鼠中，通过 5 mg/kg 静脉注射，UNC8969 显示出 7.3 小时的 T1/2。

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UNC8969 Chemical Structure

UNC8969 Chemical Structure

CAS No. : 3036049-17-6

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UNC8969 相关抗体

Top Publications Citing Use of Products

查看 TAM Receptor 亚型特异性产品:

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Axl Mer Tyro3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UNC8969 (compound 43) is a MERTK/AXL dual inhibitor with IC50s of 1.1±0.8 nM for MERTK and 5.3 ± 2.7 nM for AXL. UNC8969 also exerts a T1/2 of 7.3 h with 5 mg/kg i.v. in mice[1].

IC50 & Target

IC50: 1.1±0.8 nM (MERTK) [1], 5.3±2.7 nM (AXL)[1]
体外研究
(In Vitro)

UNC8969 (0-1000 nM, 2 h) 剂量依赖性地抑制 pMERTK 和 pAXL[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

UNC8969 相关抗体:
分子量

535.68

Formula

C29H41N7O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UNC8969 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC89693036049-17-6UNC 8969UNC-8969TAM ReceptorTyro3AxlMerInhibitorinhibitorinhibit

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HY-162406
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