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  3. Mknk1 - MAP kinase-interacting serine/threonine kinase 1 Gene

Mknk1 - MAP kinase-interacting serine/threonine kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：MAP 激酶相互作用的 丝氨酸/苏氨酸激酶 1

种属: Mus musculus

同用名: Mnk1; 2410048M24Rik

基因 ID: 17346 | 基因类型: protein coding

关于 Mknk1

Chromosome 4: 115,696,395-115,736,447 forward strand.GRCm39:CM000997.3

This gene has 14 transcripts (splice variants), 166 orthologues, 6 paralogues and is associated with 1 phenotype. Ubiquitous expression in thymus adult (RPKM 21.1), lung adult (RPKM 18.5) and 28 other tissues.

功能概要

该基因编码一种丝氨酸-苏氨酸蛋白激酶，可被细胞外信号调节激酶或 p38 丝裂原活化蛋白激酶激活，它可能在细胞因子和环境应激反应中发挥作用。这种激酶是真核翻译起始因子 4E 磷酸化所必需的，但它不是发育过程中细胞生长所必需的。该基因的可变剪接导致多个转录变体。 [RefSeq 提供，2013 年 10 月]

This gene encodes a serine-threonine protein kinase that is activated by extracellular signal-regulated kinase or p38 mitogen-activated protein kinases, and it may function in cytokine and environmental stress responses. This kinase is required for phosphorylation of eukaryotic translation initiation factor 4E but it is not required for cell growth during development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Mknk1 基因产物(5)

mRNA Protein Name
NM_001355174.1 NP_001342103.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform c
NM_021461.5 NP_067436.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform b
NM_001285488.1 NP_001272417.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform b
NM_001285487.1 NP_001272416.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform a
NM_001369238.1 NP_001356167.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform d
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
9155017 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
9155017 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IGI
IGI: 通过遗传相互作用推断
17903173 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: 通过突变表型推断
17903173 MGI
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
9155017 MGI
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
9155017 MGI
involved in response to salt stress IDA
IDA: 通过直接分析推断
9155017 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mknk1 蛋白结构

STKc_Mnk1

STKc_Mnk1: cd14174 (33 - 321)

  • 0
  • 100
  • 200
  • 300
  • 415 a.a.
蛋白主名 其他名称

MAP kinase-interacting serine/threonine-protein kinase 1

MAPK signal-integrating kinase 1

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-15514 Merestinib Inhibitor 99.99% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08473 MKNK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08474 Mknk1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08475 Mknk1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mknk1 NCBI NCBI:8569
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