2. Gene
  3. MKNK1 - MAPK interacting serine/threonine kinase 1 Gene

MKNK1 - MAPK interacting serine/threonine kinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MAPK 相互作用的丝氨酸/苏氨酸激酶 1

种属: Homo sapiens

同用名: MNK1

基因 ID: 8569 | 基因类型: protein coding

关于 MKNK1

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:46,557,407-46,604,268 (from NCBI)

This gene has 31 transcripts (splice variants), 166 orthologues and 6 paralogues. Ubiquitous expression in appendix (RPKM 4.8), pancreas (RPKM 4.3) and 25 other tissues.

功能概要

该基因编码的 Ser/Thr 蛋白激酶与 ERK1 和 p38 丝裂原活化蛋白激酶相互作用并被其激活，因此可能在对环境压力和细胞因子的反应中发挥作用。该激酶还可以通过与 eIF4G 的 C 末端区域相互作用磷酸化 eIF4E 来调节转录。已经注意到该基因的可变剪接转录物变体。[RefSeq 提供，2012 年 1 月]

This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]

MKNK1 基因产物(31)

mRNA Protein Name
NM_001377373.1 NP_001364302.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 3
NM_198973.5 NP_945324.2 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 2
XM_047433025.1 XP_047288981.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2
NM_003684.7 NP_003675.3 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 1
XM_047433042.1 XP_047288998.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4
NM_001377374.1 NP_001364303.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 2
NR_146512.2
XM_024450510.2 XP_024306278.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4
XM_047433081.1 XP_047289037.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X9
NM_001377342.1 NP_001364271.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 5
XM_047433024.1 XP_047288980.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2
NR_024175.1
NM_001377375.1 NP_001364304.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 2
XM_017002660.3 XP_016858149.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X7
NM_001377341.1 NP_001364270.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 5
XM_047433022.1 XP_047288978.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1
NR_024176.3
XM_047433059.1 XP_047289015.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5
XM_047433047.1 XP_047289003.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5
NM_001377337.1 NP_001364266.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 4
XM_006711002.4 XP_006711065.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3
NM_001377343.1 NP_001364272.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 6
NM_001135553.4 NP_001129025.2 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 3
XM_047433053.1 XP_047289009.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5
XM_047433066.1 XP_047289022.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X6
XM_047433026.1 XP_047288982.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2
NR_024174.3
NR_165250.1
NM_001377338.1 NP_001364267.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform 4
XM_047433039.1 XP_047288995.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4
XM_047433079.1 XP_047289035.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X8
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
9155018 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20936779 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
9155018 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
9155018 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
17130135 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
9155018 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MKNK1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (52 - 374)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 465 a.a.
蛋白主名 其他名称

MAP kinase-interacting serine/threonine-protein kinase 1

MAP kinase interacting serine/threonine kinase 1

MAP kinase signal-integrating kinase 1

MAPK signal-integrating kinase 1

MKNK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MKNK1 Q9BUB5 CREM Homo sapiens Q03060-25
Y2H Prey Pooling
32296183
种属内
MKNK1 Q9BUB5 CREM Homo sapiens Q03060-25
Y2H Array
32296183
种属内
MKNK1 Q9BUB5 MAPK14 Homo sapiens Q16539
Pull Down
32707033
种属内
MKNK1 Q9BUB5 MAPK1 Homo sapiens P28482
Y2H Array
32296183
种属内
MKNK1 Q9BUB5 MAPK1 Homo sapiens P28482
Y2H Prey Pooling
32296183
种属内
MKNK1 Q9BUB5 MAPK1 Homo sapiens P28482
Pull Down
32707033
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-15514 Merestinib Inhibitor 99.99% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08473 MKNK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08474 Mknk1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08475 Mknk1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MKNK1 VGNC VGNC:31491
Macaca mulatta MKNK1 VGNC VGNC:74876
Mus musculus MKNK1 MGD MGI:894316
Canis familiaris MKNK1 VGNC VGNC:54216
Rattus norvegicus MKNK1 RGD RGD:1559603
Felis catus MKNK1 VGNC VGNC:68264
Others MKNK1 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z