DMP1 - dentin matrix acidic phosphoprotein 1 Gene

中文名称：牙本质基质酸性磷蛋白 1

种属: Homo sapiens

同用名: ARHP; ARHR; DMP-1

基因 ID: 1758 | 基因类型: protein coding

关于 DMP1

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:87,650,280-87,664,357 (from NCBI)

This gene has 7 transcripts (splice variants), 109 orthologues and is associated with 3 phenotypes. Low expression observed in reference dataset.

功能概要

牙本质基质酸性磷蛋白是一种细胞外基质蛋白，是小整合素结合配体 N-连接糖蛋白家族的成员。这种蛋白质对骨骼和牙本质的正常矿化至关重要，存在于骨骼和牙齿组织的不同细胞中。该蛋白质包含大量酸性结构域、多个磷酸化位点、功能性 arg-gly-asp 细胞附着序列和 DNA 结合结构域。在未分化的成骨细胞中，它主要是一种调节成骨细胞特异性基因表达的核蛋白。在成骨细胞成熟过程中，蛋白质被磷酸化并输出到细胞外基质，在那里它协调矿化基质的形成。已知该基因的突变会导致常染色体隐性遗传性低磷血症，这是一种表现为佝偻病和骨软化症的疾病。该基因结构在哺乳动物中是保守的。已针对该基因描述了编码不同亚型的两种转录物变体。[RefSeq 提供，2008 年 7 月]

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small Integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

DMP1 基因产物(2)

mRNA	Protein	Name
NM_001079911.3	NP_001073380.1	dentin matrix acidic phosphoprotein 1 isoform 2 precursor
NM_004407.4	NP_004398.1	dentin matrix acidic phosphoprotein 1 isoform 1 precursor

DMP1 蛋白结构

DMP1

0
100
200
300
400
513 a.a.

蛋白主名

其他名称

dentin matrix acidic phosphoprotein 1

dentin matrix protein 1

重组 DMP1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70105	DMP-1 Protein, Human (HEK293, His)	Q13316 (L17-Y513)	≥95%

关联疾病

疾病名称

别名

Hypophosphatemic Rickets, Autosomal Recessive, 1

ARHR1	Arhp
Hypophosphatemic Rickets, Ar	Arhr
Hypophosphatemia, Autosomal Recessive	Hypophosphatemia Autosomal Recessive
Autosomal Recessive Hypophosphatemic Vitamin D Refractory Rickets

Hypophosphatemic Rickets, X-Linked Recessive

Hypophosphatemic Rickets	X-Linked Recessive Hypophosphatemic Rickets
XLRHR	Hypophosphatemic Rickets Disorders
Rickets Hypophosphatemic	Rickets, Hypophosphatemic, X-Linked Recessive
Familial Hypophosphatemic Rickets

Autosomal Recessive Hypophosphatemic Rickets

Arhr	Hypophosphatemic Rickets, Autosomal Recessive
Autosomal Recessive Hypophosphatemic Vitamin D Refractory Rickets

Osteomalacia

Adult Rickets

Hypophosphatemia

Vitamin D-Resistant Rickets	Hereditary Hypophosphatemic Rickets
Vdrr	Vitamin D Resistant Rickets
Hypophosphatemic Rickets, X-Linked Dominant	Familial Hypophosphatemic Rickets

Rickets

Vitamin D Deficiency	Vitamin D
Active Rickets	Hypovitaminosis D
Nutritional Rickets	Vitamin D Deficiency Disease
Vitamin-D Deficiency Rickets	Vitamin D-Dependent Rickets
Avitaminosis D	Infantile Osteomalacia
Juvenile Osteomalacia

Dentinogenesis Imperfecta

Hereditary Opalescent Dentin	Dentinogenesis Imperfecta Without Osteogenesis Imperfecta
Dgi	Capdepont Teeth
Dgi Without Oi	Di
Non-Syndromic Dgi	Non-Syndromic Dentinogenesis Imperfecta
Opalescent Teeth Without Oi	Opalescent Teeth Without Osteogenesis Imperfecta
Opalescent Dentin

Dentinogenesis Imperfecta 1

Capdepont Teeth	Dentinogenesis Imperfecta Type 2
Opalescent Dentin	Dentinogenesis Imperfecta Without Osteogenesis Imperfecta
Dgi-Ii	Dentinogenesis Imperfecta, Shields Type 2
DGI1	Opalescent Teeth Without Osteogenesis Imperfecta
Dentinogenesis Imperfecta, Shields Type Ii	Dgi-2
Di-2	DGI2
Dentinogenesis Imperfecta Shields Type Ii	Non-Syndromic Dentinogenesis Imperfecta
Non-Syndromic Dgi

Dentin Dysplasia

Dentinal Dysplasia	Dd
Dysplasia, Dentin	Shell Teeth

Raine Syndrome

Lethal Osteosclerotic Bone Dysplasia	RNS
Renal Nutcracker Syndrome	Osteomalacia, Sclerosing, With Cerebral Calcification
Left Renal Vein Entrapment Syndrome	Csocc
Osteosclerotic Bone Dysplasia, Lethal	Combination Of Microcephaly, Exophthalmos, Hypoplastic Nose And Midface, Gum Hyperplasia, Cleft Palate, Apparently Low-Set Ears, And Osteosclerosis
Nutcracker Syndrome

Vitamin D-Dependent Rickets Type 2b

Nephrolithiasis/Osteoporosis, Hypophosphatemic, 1

Hypophosphatemic Nephrolithiasis/Osteoporosis 1	NPHLOP1
Nephrolithiasis-Osteoporosis, Hypophosphatemic, 1	Nephrolithiasis/Osteoporosis, Hypophosphatemic, Type 1

Root Resorption

Dental Pulp Necrosis

Pulp Necrosis	Necrotic Pulp
Necrosis Of The Pulp	Dead Pulp
Devitalised Pulp	Putrescent Pulpitis
Devitalized Tooth	Dental Pulp Gangrene
Pulp Gangrene	Nonvital Tooth
Pulpless Tooth	Putrescent Pulp

Fanconi Renotubular Syndrome 2

FRTS2

Fanconi Renotubular Syndrome, Type 2

Hypophosphatemic Nephrolithiasis/Osteoporosis

Nephrolithiasis/Osteoporosis, Hypophosphatemic

Sclerosteosis 1

SOST1	Sost
Cortical Hyperostosis With Syndactyly	Sclerosteosis
Sclerosteosis, Type 1

Osteoglophonic Dysplasia

Osteoglophonic Dwarfism	OGD
Fairbank-Keats Syndrome	Osteoglosphonic Dysplasia
Dysplasia, Osteoglophonic

Dental Caries

Dental Caries Extending Into Pulp	Dental Caries Of Smooth Surface
Dental Caries Pit And Fissure	Smooth Surface Dental Caries
Dental Decay	Carious Teeth
Dental Cavity	Saprodontia
Teeth Decayed	Tooth Caries
Tooth Decay

Dental Pulp Disease

Dental Pulp Diseases	Dental Pulp Disorder
Disorder Of Pulp Of Tooth	Pulp Disorder

Hypophosphatemic Rickets, Autosomal Dominant

Autosomal Dominant Hypophosphatemic Rickets	ADHR
Autosomal Dominant Hypophosphatemia	Vitamin D-Resistant Rickets, Autosomal Dominant
Hypophosphatemia, Autosomal Dominant	Autosomal Dominant Vitamin D-Resistant Rickets
Rickets, Hypophosphatemic, Autosomal Dominant

Vitamin D Hydroxylation-Deficient Rickets, Type 1b

VDDR1B	Vitamin D-Dependent Rickets Type 1b
Vitamin D-Dependent Rickets, Type 1b	25-Hydroxyvitamin D3 Deficiency, Selective
Pseudovitamin D3 Deficiency Rickets Due To 25-Hydroxylase Deficiency	Rickets Due To Defect In Vitamin D 25-Hydroxylation Deficiency
Rickets Vitamin D-Dependent 1b	25-Hydroxyvitamimn D3 Deficiency Selective
25-Hydroxyvitamin D(3) Deficiency	Pseudovitamin D(3) Deficiency Rickets Due To 25-Hydroxylase Deficiency
Selective 25-Hydroxyvitamin D(3) Deficiency	Rickets Due To Defect In Vitamin D 25-Hydroxylation

Hypophosphatemic Rickets, X-Linked Dominant

X-Linked Hypophosphatemia	Xlh
Vitamin D-Resistant Rickets, X-Linked	X-Linked Hypophosphatemic Rickets
XLHR	Hyp
Hypophosphatemic Vitamin D-Resistant Rickets	Hpdr
X-Linked Dominant Hypophosphatemic Rickets	Familial Hypophosphatemic Rickets
Hypophosphatemia, X-Linked	Hypophosphatemia, Vitamin D-Resistant Rickets
Hypophosphatemic Rickets X-Linked Dominant	X-Linked Vitamin D-Resistant Rickets
Hypophophatemia, X-Linked	Hypophophatemic Vitamin D-Resistant Rickets
Hypophosphatemia X-Linked	Vitamin D-Resistant Rickets X-Linked
Vitamin D-Resistant Rickets	Rickets, X-Linked Hypophosphatemic

Vitamin D Hydroxylation-Deficient Rickets, Type 1a

Vitamin D-Dependent Rickets, Type 1a	Vitamin D-Dependent Rickets, Type 1
VDDR1A	25-Hydroxycholecalciferol-1-Hydroxylase Deficiency
1-Alpha-Hydroxylase Deficiency	Vdd1
Pddr1a	Pddr Ia
Vitamin D-Dependent Rickets, Type I	Vitamin D-Dependent Rickets Type 1a
1-Alpha, 25-Hydroxyvitamin D3 Deficiency, Selective	Vitamin D Dependency, Type 1
Pseudovitamin D-Deficiency Rickets, Type Ia	Rickets Vitamin D-Dependent 1a
1-Alpha 25-Hydroxyvitamin D3 Deficiency Selective	Pddr
Pseudovitamin D Deficiency Rickets	Pseudovitamin D-Deficiency Rickets Type Ia
Vitamin D Dependency Type 1

Familial Isolated Hypoparathyroidism

Fih

Arterial Calcification Of Infancy

Idiopathic Infantile Arterial Calcification	Generalized Arterial Calcification Of Infancy
Iiac	Occlusive Infantile Arteriopathy
Infantile Arteriosclerosis	Gaci
Idiopathic Obliterative Arteriopathy	Generalized Arterial Calcification In Infancy
Arteriopathia Calcificans Infantum	Diffuse Arterial Calcifying Elastopathy Of Infancy
Infantile Calcifying Arteriopathy	Medial Coronary Sclerosis Of Infancy
Coronary Sclerosis, Medial, Of Infancy	Calcification, Arterial, Generalized, Infancy

Dental Abscess

Vitamin D-Dependent Rickets, Type 2a

Hvdrr	Generalized Resistance To 1,25-Dihydroxyvitamin D
Hypocalcemic Vitamin D-Resistant Rickets	VDDR2A
Rickets, Hereditary Vitamin D-Resistant	Vitamin D-Resistant Rickets With End-Organ Unresponsiveness To 1,25-Dihydroxycholecalciferol
Pddr Iia	Rickets-Alopecia Syndrome
Rickets, Vitamin D-Resistant, Type Iia	Vitamin D-Dependent Rickets Type 2a
Vitamin D-Dependent Rickets, Type 2	Vitamin D-Dependent Rickets, Type 2a, With Or Without Alopecia
Generalized 1,25-Dihydroxyvitamin D	Pseudovitamin D-Deficiency, Type Iia
Hereditary Vitamin D-Resistant Rickets	Vddr Ii
Vdrr Ii	Vitamin D-Dependent Rickets Type Ii
Vitamin D-Resistant Rickets Type Ii	Rickets Vitamin D-Dependent 2a
Pseudovitamin D-Deficiency Type Iia	Rickets Hereditary Vitamin D-Resistant
Type Iia Rickets	Vitamin D-Dependent Rickets Type 2a With Or Without Alopecia
Vitamin D-Dependent Rickets, Type Ii	Familial Hypophosphatemic Rickets
Hypophosphatemic Rickets, X-Linked Dominant

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03826	DMP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	DMP1	VGNC	VGNC:57414
Mus musculus	DMP1	MGD	MGI:94910
Rattus norvegicus	DMP1	RGD	RGD:2508
Felis catus	DMP1	VGNC	VGNC:107327
Macaca mulatta	DMP1	VGNC	VGNC:71933
Bos taurus	DMP1	VGNC	VGNC:28108
Others	DMP1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DMP1 - dentin matrix acidic phosphoprotein 1 Gene

关于 DMP1

功能概要

DMP1 基因产物(2)

DMP1 蛋白结构

重组 DMP1 蛋白

关联疾病

直系同源

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DMP1 - dentin matrix acidic phosphoprotein 1 Gene

关于 DMP1

功能概要

DMP1 基因产物(2)

DMP1 蛋白结构

重组 DMP1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z