2. Gene
  3. Myh6 - myosin, heavy polypeptide 6, cardiac muscle, alpha Gene

Myh6 - myosin, heavy polypeptide 6, cardiac muscle, alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Myhca; Myhc-a; alphaMHC; alpha-MHC; A830009F23Rik

基因 ID: 17888 | 基因类型: protein coding

关于 Myh6

功能概要

Enables microfilament motor activity. Involved in cardiac muscle contraction. Acts upstream of or within several processes, including adult heart development; muscle cell development; and regulation of heart contraction. Located in Z disc and stress fiber. Part of Myosin complex. Is expressed in several structures, including brown fat; embryo mesenchyme; great vessel of heart; heart; and skeletal musculature. Used to study dilated cardiomyopathy; dilated cardiomyopathy 1EE; and hypertrophic cardiomyopathy 14. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Orthologous to human MYH6 (Myosin heavy chain 6). [provided by Alliance of Genome Resources, Apr 2022]

Myh6 基因产物(2)

mRNA Protein Name
NM_001164171.1 NP_001157643.1 myosin-6
NM_010856.4 NP_034986.1 myosin-6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables microfilament motor activity IMP
IMP: 通过突变表型推断
15001446 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17075052 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within actin filament-based movement IMP
IMP: 通过突变表型推断
15001446 MGI
acts upstream of or within adult heart development IMP
IMP: 通过突变表型推断
8878443 MGI
acts upstream of or within cardiac muscle cell development IMP
IMP: 通过突变表型推断
8878443 MGI
involved in cardiac muscle contraction IMP
IMP: 通过突变表型推断
9884344 MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress IDA
IDA: 通过直接分析推断
24137001 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
8878443 MGI
acts upstream of or within myofibril assembly IMP
IMP: 通过突变表型推断
8878443 MGI
acts upstream of or within regulation of ATP-dependent activity IMP
IMP: 通过突变表型推断
15001446 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: 通过突变表型推断
8878443 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: 通过突变表型推断
8614836 MGI
acts upstream of or within regulation of heart growth IDA
IDA: 通过直接分析推断
17379774 MGI
acts upstream of or within regulation of heart rate IMP
IMP: 通过突变表型推断
9541509 MGI
acts upstream of or within regulation of the force of heart contraction IMP
IMP: 通过突变表型推断
9541509 MGI
acts upstream of or within sarcomere organization IMP
IMP: 通过突变表型推断
8878443 MGI
acts upstream of or within striated muscle contraction IMP
IMP: 通过突变表型推断
8614836 MGI
acts upstream of or within visceral muscle development IMP
IMP: 通过突变表型推断
11708849 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Z disc IDA
IDA: 通过直接分析推断
21126233 MGI
located in myofibril IDA
IDA: 通过直接分析推断
8878443 MGI
part of myosin complex IDA
IDA: 通过直接分析推断
8482409 MGI
located in stress fiber IDA
IDA: 通过直接分析推断
21126233 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

myosin-6

alpha cardiac MHC

alpha myosin

cardiomyopathy, hypertrophic 1

myHC-alpha

myosin heavy chain 6

myosin heavy chain, cardiac muscle, adult

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08904 MYH6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Myh6 NCBI NCBI:4624
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