1. Gene
  2. Ncoa1 - nuclear receptor coactivator 1 Gene

Ncoa1 - nuclear receptor coactivator 1 Gene

种属: Mus musculus

同用名: SRC1; NRC-1; SRC-1; SRC-a; KAT13A; NCoA-1; mNRC-1; bHLHe74

基因 ID: 17977 | 基因类型: protein coding

关于 Ncoa1

功能概要

Enables DNA binding activity; chromatin binding activity; and transcription coactivator activity. Involved in several processes, including histone H4 acetylation; positive regulation of transcription from RNA polymerase II promoter by galactose; and regulation of cellular response to drug. Acts upstream of or within several processes, including cellular response to Thyroglobulin triiodothyronine; labyrinthine layer morphogenesis; and regulation of thyroid hormone mediated signaling pathway. Predicted to be located in several cellular components, including chromatin; cytosol; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; eye; and genitourinary system. Used to study obesity and thyroid hormone resistance syndrome. Orthologous to human NCOA1 (nuclear receptor coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncoa1 基因产物(11)

mRNA Protein Name
NM_001408597.1 NP_001395526.1 nuclear receptor coactivator 1 isoform 1
NM_001408598.1 NP_001395527.1 nuclear receptor coactivator 1 isoform 1
NM_001408599.1 NP_001395528.1 nuclear receptor coactivator 1 isoform 1
NM_001408600.1 NP_001395529.1 nuclear receptor coactivator 1 isoform 1
NM_001408601.1 NP_001395530.1 nuclear receptor coactivator 1 isoform 1
NM_001408602.1 NP_001395531.1 nuclear receptor coactivator 1 isoform 2
NM_001408603.1 NP_001395532.1 nuclear receptor coactivator 1 isoform 3
NM_001408604.1 NP_001395533.1 nuclear receptor coactivator 1 isoform 4
NM_001408605.1 NP_001395534.1 nuclear receptor coactivator 1 isoform 5
NM_001408606.1 NP_001395535.1 nuclear receptor coactivator 1 isoform 6
NM_010881.3 NP_035011.1 nuclear receptor coactivator 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
15681609 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
12446761 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10934189 MGI
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
16148126 MGI
enables transcription coactivator activity IMP
IMP: 通过突变表型推断
16723356 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of transcription regulator complex EXP
EXP: 通过实验结果推断
17215127 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

nuclear receptor coactivator 1

nuclear receptor coactivator protein 1

steroid receptor coactivator 1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ncoa1 NCBI NCBI:8648