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  2. Ncoa2 - nuclear receptor coactivator 2 Gene

Ncoa2 - nuclear receptor coactivator 2 Gene

种属: Mus musculus

同用名: TIF2; Grip1; SRC-2; GRIP-1; KAT13C; NCoA-2; bHLHe75; D1Ertd433e

基因 ID: 17978 | 基因类型: protein coding

关于 Ncoa2

功能概要

Enables several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and nuclear receptor coactivator activity. Involved in circadian regulation of gene expression; locomotor rhythm; and regulation of glucose metabolic process. Acts upstream of or within several processes, including cellular response to Thyroglobulin triiodothyronine; regulation of transcription by RNA polymerase II; and response to progesterone. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NCOA2 (nuclear receptor coactivator 2). [provided by Alliance of Genome Resources, Apr 2022]

Ncoa2 基因产物(2)

mRNA Protein Name
NM_001302702.1 NP_001289631.1 nuclear receptor coactivator 2 isoform b
NM_008678.3 NP_032704.2 nuclear receptor coactivator 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
24550004 MGI
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
24550004 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
15001550 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
16109736 MGI
enables nuclear receptor coactivator activity IDA
IDA: 通过直接分析推断
15072553 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8643509 MGI
enables signaling receptor binding IDA
IDA: 通过直接分析推断
8643509 MGI
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
8643509 MGI
enables transcription coactivator activity IGI
IGI: 通过遗传相互作用推断
15383530 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
12130539 MGI
part of transcription regulator complex IPI
IPI: 通过物理相互作用推断
21152046 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

nuclear receptor coactivator 2

glucocorticoid receptor interacting protein 1

steroid receptor coactivator 2

transcriptional intermediary factor 2

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ncoa2 NCBI NCBI:10499