2. Gene
  3. Ncoa2 - nuclear receptor coactivator 2 Gene

Ncoa2 - nuclear receptor coactivator 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: TIF2; Grip1; SRC-2; GRIP-1; KAT13C; NCoA-2; bHLHe75; D1Ertd433e

基因 ID: 17978 | 基因类型: protein coding

关于 Ncoa2

功能概要

Enables several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and nuclear receptor coactivator activity. Involved in circadian regulation of gene expression; locomotor rhythm; and regulation of glucose metabolic process. Acts upstream of or within several processes, including cellular response to Thyroglobulin triiodothyronine; regulation of transcription by RNA polymerase II; and response to progesterone. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NCOA2 (nuclear receptor coactivator 2). [provided by Alliance of Genome Resources, Apr 2022]

Ncoa2 基因产物(2)

mRNA Protein Name
NM_001302702.1 NP_001289631.1 nuclear receptor coactivator 2 isoform b
NM_008678.3 NP_032704.2 nuclear receptor coactivator 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
24550004 MGI
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
24550004 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
15001550 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
16109736 MGI
enables nuclear receptor coactivator activity IDA
IDA: 通过直接分析推断
15072553 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8643509 MGI
enables signaling receptor binding IDA
IDA: 通过直接分析推断
8643509 MGI
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
8643509 MGI
enables transcription coactivator activity IGI
IGI: 通过遗传相互作用推断
15383530 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to Thyroglobulin triiodothyronine IDA
IDA: 通过直接分析推断
24550004 MGI
involved in circadian regulation of gene expression IMP
IMP: 通过突变表型推断
24529706 MGI
involved in circadian rhythm IEP
IEP: 通过表达模式推断
24529706 MGI
involved in locomotor rhythm IMP
IMP: 通过突变表型推断
24529706 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
8643509 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8643509 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15383530 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12130539 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
24571987 MGI
involved in regulation of glucose metabolic process IMP
IMP: 通过突变表型推断
19039140 MGI
involved in regulation of lipid metabolic process IDA
IDA: 通过直接分析推断
31851938 MGI
acts upstream of or within response to progesterone IMP
IMP: 通过突变表型推断
24571987 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
12130539 MGI
part of transcription regulator complex IPI
IPI: 通过物理相互作用推断
21152046 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

nuclear receptor coactivator 2

glucocorticoid receptor interacting protein 1

steroid receptor coactivator 2

transcriptional intermediary factor 2

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09090 NCOA2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ncoa2 NCBI NCBI:10499
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