Ndp - Norrie disease (pseudoglioma) (human) Gene

种属: Mus musculus

同用名: ND; Ndph

基因 ID: 17986 | 基因类型: protein coding

关于 Ndp

功能概要

This gene encodes a secreted protein that acts a ligand for multiple different receptors and participates in both Wnt and Wnt-independant signalling. Its activity is important in vascular development of the eye and inner ear. Mutation of the related gene in humans causes Norrie syndrome. [provided by RefSeq, May 2015]

Ndp 基因产物(1)

mRNA	Protein	Name
NM_010883.3	NP_035013.1	norrin precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cytokine activity	IDA IDA: 通过直接分析推断	15035989	MGI
enables frizzled binding	IPI IPI: 通过物理相互作用推断	15035989	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Norrin signaling pathway	IDA IDA: 通过直接分析推断	15035989	MGI
acts upstream of or within action potential	IMP IMP: 通过突变表型推断	9071226	MGI
acts upstream of or within angiogenesis	IGI IGI: 通过遗传相互作用推断	27823583	MGI
acts upstream of or within angiogenesis	IMP IMP: 通过突变表型推断	27823583	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: 通过突变表型推断	28575130	MGI
acts upstream of or within canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	29079753	MGI
acts upstream of or within cell population proliferation	IDA IDA: 通过直接分析推断	15716406	MGI
acts upstream of or within cell population proliferation	IMP IMP: 通过突变表型推断	15716406	MGI
acts upstream of or within cellular response to hypoxia	IMP IMP: 通过突变表型推断	30988181	MGI
acts upstream of or within cone retinal bipolar cell differentiation	IMP IMP: 通过突变表型推断	9071226	MGI
acts upstream of or within dendrite development	IMP IMP: 通过突变表型推断	30936556	MGI
acts upstream of or within dendritic spine development	IMP IMP: 通过突变表型推断	30936556	MGI
acts upstream of or within endothelial cell differentiation	IMP IMP: 通过突变表型推断	23217714	MGI
acts upstream of or within establishment of blood-brain barrier	IGI IGI: 通过遗传相互作用推断	30478038	MGI
acts upstream of or within establishment of blood-brain barrier	IMP IMP: 通过突变表型推断	23217714	MGI
acts upstream of or within establishment of blood-retinal barrier	IMP IMP: 通过突变表型推断	29654250	MGI
acts upstream of or within exploration behavior	IMP IMP: 通过突变表型推断	30936556	MGI
involved in extracellular matrix-cell signaling	IDA IDA: 通过直接分析推断	15035989	MGI
acts upstream of or within gene expression	IDA IDA: 通过直接分析推断	23201751	MGI
acts upstream of or within gene expression	IMP IMP: 通过突变表型推断	22394677	MGI
acts upstream of or within glutathione metabolic process	IMP IMP: 通过突变表型推断	30988181	MGI
acts upstream of or within glycine metabolic process	IMP IMP: 通过突变表型推断	30988181	MGI
acts upstream of or within inflammatory response	IMP IMP: 通过突变表型推断	29654250	MGI
acts upstream of or within lens development in camera-type eye	IDA IDA: 通过直接分析推断	15716406	MGI
acts upstream of or within lens development in camera-type eye	IMP IMP: 通过突变表型推断	15716406	MGI
acts upstream of or within microglia differentiation	IMP IMP: 通过突变表型推断	29654250	MGI
acts upstream of or within microglial cell proliferation	IMP IMP: 通过突变表型推断	29654250	MGI
acts upstream of or within mitotic cell cycle	IMP IMP: 通过突变表型推断	22394677	MGI
acts upstream of or within neural retina development	IDA IDA: 通过直接分析推断	15716406	MGI
acts upstream of or within neural retina development	IMP IMP: 通过突变表型推断	15716406	MGI
acts upstream of or within neuron apoptotic process	IDA IDA: 通过直接分析推断	29715368	MGI
acts upstream of or within neuron differentiation	IMP IMP: 通过突变表型推断	30936556	MGI
acts upstream of or within optic nerve development	IDA IDA: 通过直接分析推断	29079753	MGI
acts upstream of or within placenta development	IMP IMP: 通过突变表型推断	16035034	MGI
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	15035989	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	15035989	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: 通过直接分析推断	29079753	MGI
acts upstream of or within protein localization	IMP IMP: 通过突变表型推断	23217714	MGI
acts upstream of or within protein phosphorylation	IDA IDA: 通过直接分析推断	29079753	MGI
acts upstream of or within protein targeting to lysosome	IMP IMP: 通过突变表型推断	28675177	MGI
acts upstream of or within protein ubiquitination	IMP IMP: 通过突变表型推断	28675177	MGI
acts upstream of or within re-entry into mitotic cell cycle	IDA IDA: 通过直接分析推断	23201751	MGI
acts upstream of or within response to axon injury	IDA IDA: 通过直接分析推断	29079753	MGI
acts upstream of or within response to hypoxia	IMP IMP: 通过突变表型推断	25414188	MGI
acts upstream of or within retina blood vessel maintenance	IMP IMP: 通过突变表型推断	28575130	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: 通过突变表型推断	9071226	MGI
acts upstream of or within retina layer formation	IMP IMP: 通过突变表型推断	29654250	MGI
acts upstream of or within retina morphogenesis in camera-type eye	IDA IDA: 通过直接分析推断	15716406	MGI
acts upstream of or within retina morphogenesis in camera-type eye	IMP IMP: 通过突变表型推断	15716406	MGI
acts upstream of or within retina vasculature development in camera-type eye	IDA IDA: 通过直接分析推断	15716406	MGI
acts upstream of or within retina vasculature development in camera-type eye	IMP IMP: 通过突变表型推断	15716406	MGI
acts upstream of or within retina vasculature morphogenesis in camera-type eye	IGI IGI: 通过遗传相互作用推断	19837032	MGI
acts upstream of or within retina vasculature morphogenesis in camera-type eye	IMP IMP: 通过突变表型推断	18978344	MGI
acts upstream of or within retinal blood vessel morphogenesis	IMP IMP: 通过突变表型推断	18978344	MGI
acts upstream of or within retinal ganglion cell axon guidance	IDA IDA: 通过直接分析推断	29079753	MGI
acts upstream of or within retinal pigment epithelium development	IMP IMP: 通过突变表型推断	9071226	MGI
acts upstream of or within retinal rod cell differentiation	IMP IMP: 通过突变表型推断	9071226	MGI
acts upstream of or within serine family amino acid metabolic process	IMP IMP: 通过突变表型推断	30988181	MGI
acts upstream of or within smoothened signaling pathway	IDA IDA: 通过直接分析推断	23201751	MGI
acts upstream of or within transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	18978344	MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway	IDA IDA: 通过直接分析推断	29715368	MGI
acts upstream of or within tricarboxylic acid cycle	IMP IMP: 通过突变表型推断	30988181	MGI
acts upstream of or within ubiquitin-dependent endocytosis	IMP IMP: 通过突变表型推断	28675177	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in collagen-containing extracellular matrix	IDA IDA: 通过直接分析推断	15035989	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

norrin

norrie disease protein homolog

重组 Ndp 蛋白

目录号	产品名	蛋白编号	纯度
HY-P79131	Norrin Protein, Mouse	P48744 (K25-S131)	≥95%

目录号	产品名	作用方式	纯度	Phase
HY-107139	JNJ-10229570	Antagonist	≥98.0%	Phase 1

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-113206	D-Sedoheptulose 7-phosphate		≥98.0%	否
HY-113206A	D-Sedoheptulose-7-phosphate barium		/	否
HY-121183	Aprikalim	Activator	/	否
HY-E70122	Uridylate kinase		/	否
HY-RS09113	NDP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Ndp	NCBI	NCBI:4693
Macaca fascicularis	Ndp	NCBI	NCBI:102117357

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Ndp - Norrie disease (pseudoglioma) (human) Gene

关于 Ndp

功能概要

Ndp 基因产物(1)

重组 Ndp 蛋白

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热门区域

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Ndp - Norrie disease (pseudoglioma) (human) Gene

关于 Ndp

功能概要

Ndp 基因产物(1)

重组 Ndp 蛋白

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z