DPP6 - dipeptidyl peptidase like 6 Gene

中文名称：二肽基肽酶样 6

种属: Homo sapiens

同用名: VF2; DPL1; DPPX; MRD33

基因 ID: 1804 | 基因类型: protein coding

关于 DPP6

Cytogenetic location: 7q36.2 Genomic coordinates (GRCh38): 7:153,748,133-154,894,285 (from NCBI)

This gene has 23 transcripts (splice variants), 280 orthologues, 6 paralogues and is associated with 4 phenotypes. Biased expression in brain (RPKM 22.2), endometrium (RPKM 11.9) and 5 other tissues.

功能概要

该基因编码单程 II 型膜蛋白，它是丝氨酸蛋白酶肽酶 S9B 家族的成员。这种蛋白质没有可检测的蛋白酶活性，很可能是由于不存在通常存在于丝氨酸蛋白酶催化结构域中的保守丝氨酸残基。然而，它确实结合了特定的电压门控钾通道并改变了它们的表达和生物物理特性。该基因的变异可能与肌萎缩侧索硬化症的易感性和特发性心室颤动有关。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 3 月]

This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

DPP6 基因产物(11)

mRNA	Protein	Name
NM_001039350.3	NP_001034439.1	dipeptidyl aminopeptidase-like protein 6 isoform 3
NM_001290252.2	NP_001277181.1	dipeptidyl aminopeptidase-like protein 6 isoform 4
NM_001290253.2	NP_001277182.1	dipeptidyl aminopeptidase-like protein 6 isoform 5
NM_001364497.2	NP_001351426.1	dipeptidyl aminopeptidase-like protein 6 isoform 6
NM_001364498.2	NP_001351427.1	dipeptidyl aminopeptidase-like protein 6 isoform 6
NM_001364499.2	NP_001351428.1	dipeptidyl aminopeptidase-like protein 6 isoform 6
NM_001364500.2	NP_001351429.1	dipeptidyl aminopeptidase-like protein 6 isoform 6
NM_001364501.2	NP_001351430.1	dipeptidyl aminopeptidase-like protein 6 isoform 7
NM_001364502.2	NP_001351431.1	dipeptidyl aminopeptidase-like protein 6 isoform 8
NM_001936.5	NP_001927.3	dipeptidyl aminopeptidase-like protein 6 isoform 2
NM_130797.4	NP_570629.2	dipeptidyl aminopeptidase-like protein 6 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
NOT enables dipeptidyl-peptidase activity	IDA IDA: 通过直接分析推断	8103397	GOA
enables potassium channel regulator activity	IDA IDA: 通过直接分析推断	18364354	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10551270	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in regulation of potassium ion transmembrane transport	IDA IDA: 通过直接分析推断	18364354	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in membrane	IDA IDA: 通过直接分析推断	18364354	GOA
part of voltage-gated potassium channel complex	IDA IDA: 通过直接分析推断	18364354	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DPP6 蛋白结构

DPPIV_N

Peptidase_S9

0
200
400
600
800
865 a.a.

蛋白主名

其他名称

dipeptidyl aminopeptidase-like protein 6

DPP VI

关联疾病

疾病名称

别名

Intellectual Developmental Disorder, Autosomal Dominant 33

MRD33	Autosomal Dominant Non-Syndromic Intellectual Disability 33
Mental Retardation, Autosomal Dominant 33	Autosomal Dominant Intellectual Developmental Disorder 33
Autosomal Dominant Mental Retardation 33	Mental Retardation, Autosomal Dominant, Type 33

Ventricular Fibrillation, Paroxysmal Familial, 2

VF2	Familial Paroxysmal Ventricular Fibrillation 2

Microcephaly, Autosomal Dominant

Autosomal Dominant Microcephaly	Microcephaly Autosomal Dominant
Autosomal Dominant Primary Microcephaly	Microcephaly With Autosomal Dominant Inheritance

Idiopathic Ventricular Fibrillation, Non Brugada Type

Familial Paroxysmal Ventricular Fibrillation, Non Brugada Type

Lateral Sclerosis

Primary Lateral Sclerosis	Adult-Onset Primary Lateral Sclerosis
Adult-Onset Pls	Motor Neuron Disease
Pls	Pls - [Primary Lateral Sclerosis]
Lateral Spinal Sclerosis	Lateral Complete Paralysis
Lateral Incomplete Paralysis	Lateral Paralysis

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

La Crosse Encephalitis

California Encephalitis	California Virus Encephalitis
Neuroinvasive California Encephalitis Virus Infection	Californian Encephalitis
Encephalitis, California	California Meningoencephalitis
California Encephalitis Virus Infection	California Encephalitis Virus Infection Neuroinvasive Disease
California Meningoencephalitis Virus Disease	California Serogroup Virus Neuroinvasive Disease
California Viral Encephalitis	Ce - [California Encephalitis]
Lac - [La Crosse Encephalitis]

Autoimmune Epilepsy

Stiff-Person Syndrome

SPS	Stiff-Man Syndrome
Stiff Man Syndrome	Stiff Person Syndrome
Moersch-Woltman Syndrome	Sms
Stiff-Trunk Syndrome	Morsch Woltman Syndrome
Stiff Person Syndrome And Related Disorders	Stiff Person Spectrum Disorder
Classic Stiff Person Syndrome	Classic Sps
Focal Stiff Limb Syndrome	Focal Stiff-Person Syndrome
Stiff Leg Syndrome	Progressive Encephalomyelitis With Rigidity

Limbic Encephalitis

Whipple Disease

Intestinal Lipodystrophy	Whipple'S Disease
Intestinal Lipophagic Granulomatosis	Secondary Non-Tropical Sprue
Tropheryma Whippelii Infection	Whipples Disease

Acute Disseminated Encephalomyelitis

Acute Disseminated Encephalitis	Adem
Ade	Encephalomyelitis Acute Disseminated
Encephalomyelitis, Acute Disseminated	Adem - [Acute Disseminated Encephalomyelitis]

Hyperekplexia

Hereditary Hyperekplexia	Kok Disease
Congenital Stiff Man Syndrome	Familial Startle Disease
Sthe	Stiff-Baby Syndrome
Hereditary Hyperexplexia	Startle Disease
Exaggerated Startle Reaction	Hyperexplexia Hereditary
Startle Disease, Familial	Startle Reaction, Exaggerated
Stiff-Man Syndrome, Congenital	Stiff-Person Syndrome, Congenital
Congenital Stiff-Man Syndrome	Congenital Stiff-Person Syndrome
Familial Hyperekplexia	Startle Syndrome
Stiff Baby Syndrome	Hyperekplexia, Hereditary
Stiff-Person Syndrome

Von Economo'S Disease

Encephalitis Lethargica	Von Economo Encephalitis
Von Economo Disease

Postinfectious Encephalitis

Postinfective Encephalitis

Secondary Encephalitis

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Mutism

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hereditary Haemochromatosis	Hlah
Hfe	Hemochromatosis, Hereditary
Diabetes Bronze	Classic Hemochromatosis
Hfe-Associated Hereditary Hemochromatosis	Hemochromatosis Classic
Bronzed Cirrhosis	Familial Hemochromatosis
Genetic Hemochromatosis	Hc
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

Choreatic Disease

Chorea

Hereditary Chorea

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03966	DPP6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	DPP6	MGD	MGI:94921
Bos taurus	DPP6	VGNC	VGNC:106716
Canis familiaris	DPP6	VGNC	VGNC:40075
Felis catus	DPP6	VGNC	VGNC:61605
Macaca mulatta	DPP6	VGNC	VGNC:71980
Rattus norvegicus	DPP6	RGD	RGD:68402

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DPP6 - dipeptidyl peptidase like 6 Gene

关于 DPP6

功能概要

DPP6 基因产物(11)

DPP6 蛋白结构

关联疾病

直系同源

热门区域

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DPP6 - dipeptidyl peptidase like 6 Gene

关于 DPP6

功能概要

DPP6 基因产物(11)

DPP6 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z