2. Gene
  3. Nos2 - nitric oxide synthase 2, inducible Gene

Nos2 - nitric oxide synthase 2, inducible Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：一氧化氮合酶 2 ，可诱导

种属: Mus musculus

同用名: iNOS; Nos-2; Nos2a; i-NOS; NOS-II; MAC-NOS

基因 ID: 18126 | 基因类型: protein coding

关于 Nos2

Chromosome 11: 78,811,613-78,851,080 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 167 orthologues, 5 paralogues and is associated with 136 phenotypes. Biased expression in large intestine adult (RPKM 3.6), ovary adult (RPKM 13.) and 6 other tissues.

功能概要

一氧化氮是一种反应性自由基，它在几个过程中充当生物介质，包括神经传递和抗微生物和抗肿瘤活性。该基因编码一氧化氮合酶，可由脂多糖和某些细胞因子的组合诱导。已发现该基因编码两种不同亚型的三种转录变体。 [RefSeq 提供，2015 年 9 月]

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase that is inducible by a combination of lipopolysaccharide and certain cytokines. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Nos2 基因产物(3)

mRNA Protein Name
NM_010927.4 NP_035057.1 nitric oxide synthase, inducible isoform a
NM_001313922.1 NP_001300851.1 nitric oxide synthase, inducible isoform b
NM_001313921.1 NP_001300850.1 nitric oxide synthase, inducible isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables FMN binding IDA
IDA: 通过直接分析推断
1383204 MGI
enables arginine binding IDA
IDA: 通过直接分析推断
9271491 MGI
enables flavin adenine dinucleotide binding IDA
IDA: 通过直接分析推断
1383204 MGI
enables heme binding IDA
IDA: 通过直接分析推断
1383204 MGI
enables nitric-oxide synthase activity IDA
IDA: 通过直接分析推断
1383204 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12855682 MGI
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
9271491 MGI
enables tetrahydrobiopterin binding IDA
IDA: 通过直接分析推断
9271491 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in arginine catabolic process IDA
IDA: 通过直接分析推断
1383204 MGI
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: 通过直接分析推断
18025219 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: 通过直接分析推断
18025219 MGI
acts upstream of or within cellular response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
24486487 MGI
involved in circadian rhythm IEP
IEP: 通过表达模式推断
22073225 MGI
acts upstream of or within defense response to bacterium IMP
IMP: 通过突变表型推断
12933833 MGI
involved in negative regulation of gene expression IGI
IGI: 通过遗传相互作用推断
12085352 MGI
involved in negative regulation of protein catabolic process IDA
IDA: 通过直接分析推断
18003616 MGI
involved in nitric oxide biosynthetic process IDA
IDA: 通过直接分析推断
1383204 MGI
NOT acts upstream of or within ovulation from ovarian follicle IMP
IMP: 通过突变表型推断
11779605 MGI
involved in peptidyl-cysteine S-nitrosylation IDA
IDA: 通过直接分析推断
16373578 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
11606502 MGI
acts upstream of or within response to bacterium IEP
IEP: 通过表达模式推断
23012479 MGI
acts upstream of or within response to hypoxia IDA
IDA: 通过直接分析推断
12960352 MGI
involved in response to lipopolysaccharide IDA
IDA: 通过直接分析推断
22073225 MGI
acts upstream of or within superoxide metabolic process IMP
IMP: 通过突变表型推断
12933833 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cortical cytoskeleton IDA
IDA: 通过直接分析推断
12960352 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
11732991 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
12960352 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Nos2 蛋白结构

NOS_oxygenase_euk

NOS_oxygenase_euk: cd00795 (77 - 489)

Flavodoxin_1

Flavodoxin_1: pfam00258 (534 - 665)

FNR_like

FNR_like: cl06868 (729 - 1125)

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  • 1144 a.a.
蛋白主名 其他名称

nitric oxide synthase, inducible

NOS type II

inducible NO synthase

inducible NOS

inducible nitric oxide synthase

macrophage NOS

nitric oxide synthase 2, inducible, macrophage

peptidyl-cysteine S-nitrosylase NOS2

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-18732A L-NMMA acetate Inhibitor ≥99.0% Phase 4
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12124 BBS-4 Inhibitor 99.51% 否
HY-RS09438 Nos2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-152213 BET-IN-13 Inhibitor / 否
HY-RS09437 NOS2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09439 NOS2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nos2 NCBI NCBI:4843
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