Sigmar1 - sigma non-opioid intracellular receptor 1 Gene

中文名称：西格玛非阿片类细胞内受体 1

种属: Mus musculus

同用名: Oprs1; Sig1R; sigma1R

关于 Sigmar1

功能概要

该基因编码位于内质网中的跨膜蛋白。编码的蛋白质是一种受体，可结合多种内源性配体，包括 N,N-二甲基色胺、孕酮和孕烯醇酮以及多种非阿片类化合物。编码的蛋白质在调节离子通道的活性方面发挥作用，充当伴侣并保护细胞免受氧化应激。在人类中，这种受体与阿尔茨海默病和帕金森病、中风以及抑郁症、疼痛和成瘾等多种疾病有关。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2013 年 11 月]

This gene encodes a transmembrane protein located in the endoplasmic reticulum. The encoded protein is a receptor that binds several endogenous ligands, including N,N-dimethyltryptamine, progesterone and pregnenolone and a variety of of non-opiate compounds. The encoded protein plays a role in regulating the activity of ion channels, acting as a chaperone and protecting cells from oxidative stress. In humans, this receptor has been associated with Alzheimer's and Parkinson's diseases, stroke and numerous disease conditions such as depression, pain and addiction. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2013]