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  3. P2rx4 - purinergic receptor P2X, ligand-gated ion channel 4 Gene

P2rx4 - purinergic receptor P2X, ligand-gated ion channel 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：嘌呤能受体 P2 X，配体门控离子通道 4

种属: Mus musculus

同用名: P2X4; D5Ertd444e

基因 ID: 18438 | 基因类型: protein coding

关于 P2rx4

Chromosome 5: 122,845,607-122,867,801 forward strand.GRCm39:CM000998.3

This gene has 9 transcripts (splice variants), 211 orthologues, 6 paralogues and is associated with 13 phenotypes. Ubiquitous expression in colon adult (RPKM 57.8), lung adult (RPKM 28.) and 23 other tissues.

功能概要

该基因编码的蛋白可启动细胞外 ATP 门控阳离子通道活动。作用于多个过程的上游或内部，包括兴奋性突触后电位；一氧化氮生物合成过程；和血管扩张。位于细胞顶端。以多种结构表达，包括心血管系统；直觉;免疫系统;神经系统;和内脏颅骨。与人 P2RX4（嘌呤能受体 P2X 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables extracellularly ATP-gated cation channel activity. Acts upstream of or within several processes, including excitatory postsynaptic potential; nitric oxide biosynthetic process; and vasodilation. Located in apical part of cell. Is expressed in several structures, including cardiovascular system; gut; immune system; nervous system; and viscerocranium. Orthologous to human P2RX4 (purinergic receptor P2X 4). [provided by Alliance of Genome Resources, Apr 2022]

P2rx4 基因产物(6)

mRNA Protein Name
NM_001310720.1 NP_001297649.1 P2X purinoceptor 4 isoform 3
NM_011026.3 NP_035156.2 P2X purinoceptor 4 isoform 1
NM_001310718.1 NP_001297647.1 P2X purinoceptor 4 isoform 2
NM_001310718.1 NP_001297647.1 P2X purinoceptor 4 isoform 2
NM_001310720.1 NP_001297649.1 P2X purinoceptor 4 isoform 3
NM_011026.3 NP_035156.2 P2X purinoceptor 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables extracellularly ATP-gated monoatomic cation channel activity IMP
IMP: 通过突变表型推断
15081800 MGI
enables ligand-gated monoatomic cation channel activity IDA
IDA: 通过直接分析推断
27477609 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within calcium ion transport IMP
IMP: 通过突变表型推断
16327800 MGI
acts upstream of or within excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
16943557 MGI
acts upstream of or within nitric oxide biosynthetic process IDA
IDA: 通过直接分析推断
16327800 MGI
acts upstream of or within nitric oxide biosynthetic process IMP
IMP: 通过突变表型推断
16327800 MGI
acts upstream of or within vasodilation IMP
IMP: 通过突变表型推断
16327800 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
17560948 MGI
is active in lysosomal membrane IDA
IDA: 通过直接分析推断
27477609 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2rx4 蛋白结构

P2X_receptor

P2X_receptor: pfam00864 (12 - 360)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
蛋白主名 其他名称

P2X purinoceptor 4

ionotropic purinergic receptor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09906 P2RX4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09907 P2rx4 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09908 P2rx4 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens P2rx4 NCBI NCBI:5025
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