2. Gene
  3. P2rx7 - purinergic receptor P2X, ligand-gated ion channel, 7 Gene

P2rx7 - purinergic receptor P2X, ligand-gated ion channel, 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：嘌呤能受体 P2 X，配体门控离子通道，7

种属: Mus musculus

同用名: P2X7R; P2X(7)

基因 ID: 18439 | 基因类型: protein coding

关于 P2rx7

Chromosome 5: 122,781,974-122,829,495 forward strand.GRCm39:CM000998.3

This gene has 8 transcripts (splice variants), 195 orthologues, 6 paralogues and is associated with 27 phenotypes. Ubiquitous expression in subcutaneous fat pad adult (RPKM 4.7), lung adult (RPKM 4.4) and 28 other tissues.

功能概要

该基因编码的蛋白可启动多项功能，包括 ATP 绑定活动；细胞外 ATP 门控阳离子通道活性；和脂多糖结合活性。参与细胞体积和疼痛感觉的负调节。作用于多个过程的上游或内部，包括有机磷酸酯运输；细胞因子产生的正调节；和分泌的正调节。位于多个细胞成分中，包括质膜的外侧；神经肌肉接头;和神经细胞体。是质膜的组成部分。在大脑中表达；心;和后肾。与人 P2RX7（嘌呤能受体 P2X 7）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and lipopolysaccharide binding activity. Involved in negative regulation of cell volume and sensory perception of pain. Acts upstream of or within several processes, including organophosphate ester transport; positive regulation of cytokine production; and positive regulation of secretion. Located in several cellular components, including external side of plasma membrane; neuromuscular junction; and neuronal cell body. Is integral component of plasma membrane. Is expressed in brain; heart; and metanephros. Orthologous to human P2RX7 (purinergic receptor P2X 7). [provided by Alliance of Genome Resources, Apr 2022]

P2rx7 基因产物(5)

mRNA Protein Name
NM_011027.4 NP_035157.2 P2X purinoceptor 7 isoform a
NM_001284402.2 NP_001271331.1 P2X purinoceptor 7 isoform e
NM_001038839.3 NP_001033928.1 P2X purinoceptor 7 isoform c
NM_001038887.2 NP_001033976.1 P2X purinoceptor 7 isoform d
NM_001038845.3 NP_001033934.1 P2X purinoceptor 7 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IMP
IMP: 通过突变表型推断
12677010 MGI
enables channel activity IMP
IMP: 通过突变表型推断
18519738 MGI
enables extracellularly ATP-gated monoatomic cation channel activity IMP
IMP: 通过突变表型推断
12677010 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15713258 MGI
enables lipopolysaccharide binding IDA
IDA: 通过直接分析推断
11489964 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15331634 MGI
enables signaling receptor activity IMP
IMP: 通过突变表型推断
12677010 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of MAPK cascade IMP
IMP: 通过突变表型推断
15937334 MGI
acts upstream of or within NAD transport IMP
IMP: 通过突变表型推断
17803959 MGI
acts upstream of T cell apoptotic process IMP
IMP: 通过突变表型推断
16325464 MGI
acts upstream of or within T cell homeostasis IMP
IMP: 通过突变表型推断
16116196 MGI
acts upstream of T cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
14761980 MGI
acts upstream of or within T cell proliferation IMP
IMP: 通过突变表型推断
15914561 MGI
acts upstream of or within bleb assembly IMP
IMP: 通过突变表型推断
17135244 MGI
involved in bleb assembly IMP
IMP: 通过突变表型推断
25651887 MGI
acts upstream of or within calcium ion transport IMP
IMP: 通过突变表型推断
12370338 MGI
acts upstream of or within cell morphogenesis IMP
IMP: 通过突变表型推断
12055263 MGI
acts upstream of or within cell volume homeostasis IDA
IDA: 通过直接分析推断
18097031 MGI
acts upstream of or within cellular response to dsRNA IMP
IMP: 通过突变表型推断
24114535 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: 通过直接分析推断
23479225 MGI
acts upstream of or within cellular response to stimulus IMP
IMP: 通过突变表型推断
18082965 MGI
acts upstream of or within ceramide biosynthetic process IDA
IDA: 通过直接分析推断
16325464 MGI
acts upstream of or within collagen metabolic process IMP
IMP: 通过突变表型推断
16969386 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: 通过突变表型推断
11544318 MGI
acts upstream of establishment of localization in cell IDA
IDA: 通过直接分析推断
15240711 MGI
acts upstream of or within establishment of localization in cell IDA
IDA: 通过直接分析推断
18097031 MGI
acts upstream of establishment of localization in cell IMP
IMP: 通过突变表型推断
16269410 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
12370338 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
17286969 MGI
acts upstream of gamma-aminobutyric acid secretion IMP
IMP: 通过突变表型推断
15640761 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
18519738 MGI
acts upstream of glutamate secretion IMP
IMP: 通过突变表型推断
15640761 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: 通过突变表型推断
16969386 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
12055263 MGI
acts upstream of interleukin-1 alpha production IMP
IMP: 通过突变表型推断
18490713 MGI
acts upstream of interleukin-1 beta production IMP
IMP: 通过突变表型推断
11016935 MGI
acts upstream of interleukin-6 production IMP
IMP: 通过突变表型推断
11016935 MGI
acts upstream of lymphocyte apoptotic process IMP
IMP: 通过突变表型推断
16493071 MGI
acts upstream of macrophage cytokine production IMP
IMP: 通过突变表型推断
11016935 MGI
acts upstream of or within membrane protein ectodomain proteolysis IMP
IMP: 通过突变表型推断
17286969 MGI
acts upstream of mitochondrial depolarization IMP
IMP: 通过突变表型推断
16198349 MGI
acts upstream of or within mitochondrion organization IDA
IDA: 通过直接分析推断
16325464 MGI
acts upstream of or within monoatomic cation transport IMP
IMP: 通过突变表型推断
12677010 MGI
acts upstream of or within negative regulation of MAPK cascade IDA
IDA: 通过直接分析推断
11489964 MGI
acts upstream of or within negative regulation of bone resorption IMP
IMP: 通过突变表型推断
12677010 MGI
involved in negative regulation of cell volume IMP
IMP: 通过突变表型推断
25651887 MGI
acts upstream of or within phagolysosome assembly IMP
IMP: 通过突变表型推断
11544318 MGI
acts upstream of or within phospholipid transfer to membrane IMP
IMP: 通过突变表型推断
12370338 MGI
acts upstream of or within phospholipid translocation IDA
IDA: 通过直接分析推断
18097031 MGI
acts upstream of or within plasma membrane organization IDA
IDA: 通过直接分析推断
18097031 MGI
acts upstream of or within pore complex assembly IMP
IMP: 通过突变表型推断
12370338 MGI
acts upstream of or within positive regulation of MAP kinase activity IMP
IMP: 通过突变表型推断
17306762 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
15937334 MGI
acts upstream of or within positive regulation of T cell apoptotic process IMP
IMP: 通过突变表型推断
16325464 MGI
acts upstream of or within positive regulation of T cell mediated cytotoxicity IMP
IMP: 通过突变表型推断
14761980 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
16969386 MGI
acts upstream of or within positive regulation of bone mineralization IMP
IMP: 通过突变表型推断
12677010 MGI
acts upstream of or within positive regulation of catalytic activity IMP
IMP: 通过突变表型推断
14761980 MGI
acts upstream of or within positive regulation of gamma-aminobutyric acid secretion IMP
IMP: 通过突变表型推断
15640761 MGI
acts upstream of or within positive regulation of glutamate secretion IMP
IMP: 通过突变表型推断
15640761 MGI
acts upstream of or within positive regulation of interleukin-1 alpha production IMP
IMP: 通过突变表型推断
18490713 MGI
acts upstream of or within positive regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
11016935 MGI
acts upstream of or within positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
11016935 MGI
acts upstream of or within positive regulation of lymphocyte apoptotic process IMP
IMP: 通过突变表型推断
16493071 MGI
acts upstream of or within positive regulation of macrophage cytokine production IMP
IMP: 通过突变表型推断
11016935 MGI
acts upstream of or within positive regulation of mitochondrial depolarization IMP
IMP: 通过突变表型推断
16198349 MGI
acts upstream of or within positive regulation of ossification IMP
IMP: 通过突变表型推断
16269410 MGI
acts upstream of or within positive regulation of prostaglandin secretion IMP
IMP: 通过突变表型推断
16269410 MGI
acts upstream of or within positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
15937334 MGI
acts upstream of or within positive regulation of protein secretion IDA
IDA: 通过直接分析推断
15240711 MGI
acts upstream of or within programmed cell death IDA
IDA: 通过直接分析推断
16116196 MGI
acts upstream of or within programmed cell death IMP
IMP: 通过突变表型推断
14761980 MGI
acts upstream of prostaglandin secretion IMP
IMP: 通过突变表型推断
16269410 MGI
acts upstream of or within protein catabolic process IDA
IDA: 通过直接分析推断
11489964 MGI
acts upstream of or within protein phosphorylation IMP
IMP: 通过突变表型推断
17306762 MGI
acts upstream of or within protein processing IMP
IMP: 通过突变表型推断
11016935 MGI
acts upstream of protein secretion IDA
IDA: 通过直接分析推断
15240711 MGI
acts upstream of or within reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
17448897 MGI
acts upstream of or within release of sequestered calcium ion into cytosol IMP
IMP: 通过突变表型推断
18082965 MGI
acts upstream of or within response to ATP IDA
IDA: 通过直接分析推断
15240711 MGI
acts upstream of or within response to ATP IMP
IMP: 通过突变表型推断
11016935 MGI
acts upstream of or within response to bacterium IMP
IMP: 通过突变表型推断
10395640 MGI
acts upstream of or within response to calcium ion IDA
IDA: 通过直接分析推断
15240711 MGI
acts upstream of or within response to calcium ion IMP
IMP: 通过突变表型推断
15978588 MGI
acts upstream of or within response to electrical stimulus IMP
IMP: 通过突变表型推断
15640761 MGI
acts upstream of or within response to fluid shear stress IMP
IMP: 通过突变表型推断
16269410 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: 通过直接分析推断
15240711 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: 通过突变表型推断
12055263 MGI
acts upstream of or within response to mechanical stimulus IMP
IMP: 通过突变表型推断
16269410 MGI
acts upstream of or within response to organic cyclic compound IDA
IDA: 通过直接分析推断
15240711 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: 通过突变表型推断
18082965 MGI
acts upstream of or within response to zinc ion IMP
IMP: 通过突变表型推断
15978588 MGI
involved in sensory perception of pain IMP
IMP: 通过突变表型推断
15777864 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: 通过突变表型推断
18519738 MGI
acts upstream of or within synaptic vesicle exocytosis IMP
IMP: 通过突变表型推断
15713258 MGI
acts upstream of or within vesicle budding from membrane IMP
IMP: 通过突变表型推断
15905573 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IDA
IDA: 通过直接分析推断
15331634 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
17286969 MGI
located in membrane IDA
IDA: 通过直接分析推断
15713258 MGI
located in neuromuscular junction IDA
IDA: 通过直接分析推断
15713258 MGI
is active in neuromuscular junction IPI
IPI: 通过物理相互作用推断
15713258 MGI
located in neuronal cell body IDA
IDA: 通过直接分析推断
15964665 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
15331634 MGI
located in plasma membrane IMP
IMP: 通过突变表型推断
12677010 MGI
located in synapse IDA
IDA: 通过直接分析推断
18082965 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2rx7 蛋白结构

P2X_receptor

P2X_receptor: pfam00864 (10 - 389)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 595 a.a.
蛋白主名 其他名称

P2X purinoceptor 7

ATP receptor

P2X7 purinoceptor

P2X7 receptor

P2Z receptor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09911 P2RX7 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09912 P2rx7 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09913 P2RX7 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens P2rx7 NCBI NCBI:5027
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z